Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma

Carcinoma, Hepatocellular Clinical Trial

Official title: Makuuchi Versus Barcelona Clinic of Liver Cancer Criteria in Cirrhotic Patients With Hepatocellular Carcinoma. Does Etiology of Cirrhosis Influence the Relationship Between the Portal Pressure and Quantitative Tests of Liver Function?

Status Completed

Clinical Trial Summary

The aim of the investigators' study is to elucidate the relationship between a functional liver test (e.g., ICG) and the PREOPERATIVE value of portal hypertension in the patients with impaired liver function from alcoholic and non-alcoholic aetiologies. Alcoholic and viral cirrhosis present important differences in terms of cellular mechanisms responsible for the disease progression with a distinct and unique gene expression pattern that regulates the type of inflammatory response. These differences probably influence the hepatic functional reserve and the onset of portal hypertension at a comparable clinical and biological level of derangement and the investigators may expect significant differences in the recovery from hepatectomy.

The investigators' hypothesis is that at a comparable ICGR-15 rate non-viral cirrhotic liver presents higher portal pressure values and the investigators also argue that alcoholic cirrhotic patients would tolerate a larger hepatic resection than would viral cirrhotic do.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Alcoholic Cirrhosis
• Carcinoma
• Carcinoma, Hepatocellular
• Fibrosis
• Liver Cirrhosis
• Liver Cirrhosis, Alcoholic
• Liver Failure
• Postoperative Hepatic Failure
• Viral Cirrhosis

• NCT number: NCT00827723
• Study type: Observational
• Source: University of Lausanne Hospitals
• Status: Completed
• Start date: February 2009
• Completion date: November 2018