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Carbohydrate&Lipid Metabolism clinical trials

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NCT ID: NCT00652405 Completed - Type 2 Diabetes Clinical Trials

Effect of Alcohol on Cephalic Phase Reflex and Gene Expression

AR22
Start date: May 2008
Phase: N/A
Study type: Interventional

Moderate alcohol consumption has consistently been associated with lowered risk of developing type two diabetes mellitus compared to abstainers and heavy drinkers. However, the underlying mechanism for the lower risk of type two diabetes is not clear. Hypothesis: moderate alcohol consumption for four weeks changes gene expression pathways of inflammatory status, insulin sensitivity and lipid and carbohydrate metabolism in adipose tissue in both lean and obese postmenopausal women. Hypothesis: Oral sensory stimulation by means of alcohol in the oral cavity will induce a cephalic phase reflex as indicated by increased autonomic & endocrine responses in postmenopausal women.