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Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE) — RAISE  

Cancer Clinical Trial

Official title:
Selpercatinib to Enhance RAI Avidity in Children, Adolescents, and Young Adults With Newly Diagnosed Differentiated Thyroid Cancers Harboring RET Fusions

Clinical Trial Summary

Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy. However, less than a quarter of patients with lung metastases will achieve a complete response to RAI therapy, and this therapy carries the risk of pulmonary fibrosis and an increasingly recognized risk of secondary malignancies.

Clinical Trial Description

This will be an open label, non-randomized study to evaluate the efficacy and safety of the combination of selpercatinib followed by 131I therapy for patients with RET fusion differentiated thyroid cancer. The primary Phase II objective will be to evaluate the pulmonary structural response rate at 18 months to the combination of selpercatinib given for 6-months followed by 131I therapy. This is exempt from Investigational New Drug requirements per the FDA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06458036
Study type Interventional
Source Children's Hospital of Philadelphia
Contact Shelby Brizzolara-Dove
Phone 267-426-9293
Email 23DT022@chop.edu
Status Not yet recruiting
Phase Phase 2
Start date August 1, 2024
Completion date August 1, 2031
View Details
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