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Combination of Carboplatin, Eribulin Mesylate, and E7449 in BRCA-Related Cancers

Cancer of the Breast Clinical Trial

Official title:
Phase I/II Clinical Trial of the Combination of Carboplatin, Eribulin Mesylate, and E7449 in Patients With BRCA-Related Cancers

Clinical Trial Summary

Non-randomized, open-label, multi-center, phase I/II, dose-escalation study of the combination of carboplatin, eribulin, and E7449.

Clinical Trial Description

This is a phase I/II clinical trial of the combination of carboplatin, eribulin, and E7449. A cycle will be defined as 21 days. Carboplatin will be given on day 1 of each cycle. Eribulin will be given on days 1 and 8 of each cycle. E7449 will be given daily (days 1-21) during each cycle. Patients will continue to receive treatment until progression of disease or discontinuation due to unacceptable side effects. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02396433
Study type Interventional
Source The University of Texas Health Science Center at San Antonio
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date April 2015
Completion date April 2015
View Details
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