Gastric Cancer Clinical Trial
Official title:
Analysis of Sarcopenia and Body Composition in Relation to Outcome in a Cohort of Patients With Esophageal Cancer or Cancer of the Gastroesophageal Junction Before and After Surgery With Curative Intent
The occurrence of dysphagia is a well-known early feature of esophageal cancer that may
reduce caloric intake and thus cause weight loss. Sarcopenia is considered to be a
consequence of such involuntary nutritional restriction. The prevalence of sarcopenia in
patients with esophageal cancer before and after surgery is not well known and its possible
consequences have been debated.
Aim: The aim of this study was to prospectively explore body composition and function in a
cohort of patients with esophageal cancer before and after surgery with curative intent. In
particular, to investigate the prevalence and development of sarcopenia and body composition
as a consequence to surgery for esophageal cancer and the possible relation to morbidity,
length of stay and quality of life (QoL).
Methods: In a cohort of 76 patients who had esophageal- or cardia-cancer and were planned for
surgery with a curative intent, data on body-composition measured with bioimpedance, working
capacity (cardiac stress test), grip strength and QoL (European Organisation for Research and
Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 version 3.0) were
prospectively collected. Data regarding dysphagia was derived from an esophagus related
quality of life form (EORTC QLQ-OES18). Data on tumour stage and type, complications, length
of stay and preoperative weight loss were collected from medical charts.
n/a
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