The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

Cancer of Endometrium Clinical Trial

Official title:

The Effect of Inhalation Anesthesia and Total Intravenous Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04891146
• Other study ID #: AbdurrahmanYAOTRH
• Status: Completed
• Start date: March 5, 2020
• Est. completion date: December 12, 2020

Study information

• Verified date: March 2021
• Source: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer surgeries.

Description:

The study was planned prospectively, observationally, on a total of 90 patients who underwent major abdominal cancer surgery. 84 patients were evaluated. The patients were seperated in two groups as inhalation anesthesia and total intravenous anesthesia (TIVA). The demographic data of the patients, type of cancer, type of surgery performed, ASA classification, preoperative chemotherapy intake, preoperative hemogram, postoperative 2nd and 24th hour hemogram, intraoperative and postoperative blood transfusion, and duration of surgery were recorded. Platelet, neutrophil, lymphocyte and SII values were saved.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 84
• Est. completion date: December 12, 2020
• Est. primary completion date: September 15, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• major abdominal cancer surgeries

Exclusion Criteria:

• blood transfusion in last 72 hours
• patients with infection
• hematologic malignancy
• patient controlled analgesia

Related Conditions & MeSH terms

• Cancer of Endometrium
• Endometrial Neoplasms

Intervention

Other:
• Systemic inflammatory immmune index
Systemic Inflammatory Immune index calculated from platelet, neutrophil and lymphocyte count

Locations

Country	Name	City	State
Turkey	Dr. Abdurrahman Yurtaslan Oncology Research and Trainee Hospital	Ankara	Yenimahalle

Sponsors (1)

Lead Sponsor	Collaborator
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, Zhang X, Wang WM, Qiu SJ, Zhou J, Fan J. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014 Dec 1;20(23):6212-22. doi: 1 — View Citation

Lee JH, Kang SH, Kim Y, Kim HA, Kim BS. Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study. Korean J Anesthesiol. 2016 Apr;69(2):126-32. doi: 10.40 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	investigate the effect of anesthesia management on the change of preoperative systemic inflammatory immune index(SII) and postoperative 2.hour and 24.hour SII value	systemic inflammatory immune index calculated by (platelet x neutrophil)/lymphocyte	preoperative SII noted, postoperative 2.hour noted and postoperative 24.hour noted