Clinical Trials Logo
  1. Home
  2. Cancer of Colon
  3. NCT05916001

Preoperative Immunonutrition in Patients Undergoing Elective Colorectal Surgery for Neoplasm

Cancer of Colon Clinical Trial

Official title:
Multicenter RCT on Effects of Preoperative Immunonutrition on Patients Undergoing Elective Colorectal Surgery for Neoplasm: Changes in Adipose Tissue Inflammation and Correlation With Surgical Outcome for Future ERAS Guidelines.

Clinical Trial Summary

Enhanced Recovery After Surgery (ERAS) protocols were developed to standardize perioperative practice in colon surgery to reduce morbidity, improve recovery, and shorten length of stay (LOS). Better protocol adherence translates into fewer readmissions and complications, and better 5-year survival. Preoperative elements, especially nutrition and immunonutrition, are topics that need further development to become the standard of care. It has been widely reported that the prevalence of malnutrition reaches 40% in cancer patients at the time of diagnosis. Impaired nutritional status at the time of surgery and cancer-induced inflammation, along with postoperative inflammatory responses to major surgery, increase the risk of postoperative complications, along with a decrease in perceived quality of life. Immunonutrition can modulate inflammation and reduce postoperative infections and shorten length of stay by counteracting the immune response induced by cancer. Adipose tissue has been shown to be a relevant source of inflammatory mediators, which may play a role in the promotion of tumor cachexia. The present study is a multicenter randomized control study (RCT) designed to evaluate the effect of preoperative immunonutrition in patients with colorectal cancer eligible for elective minimally invasive procedures, evaluating in particular surgical site infection and length of hospital stay. A biopsy of subcutaneous adipose tissue and visceral adipose tissue will also be performed, in order to evaluate the differences between inflammatory infiltrate, degree of fibrosis and cross-sectional area of adipocytes compared to controls.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05916001
Study type Interventional
Source University of Roma La Sapienza
Contact
Status Not yet recruiting
Phase N/A
Start date July 1, 2023
Completion date October 31, 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05982184 - Effect of Music Prehabilitation on Preoperative Anxiety Before Surgery N/A
Completed NCT04160650 - Educational Nursing Intervention Among Patients With Colorectal Cancer During Chemotherapy N/A
Recruiting NCT05179824 - Tempus Priority Study: A Pan-tumor Observational Study
Completed NCT04716010 - Developing and Evaluating Product Messaging N/A
Terminated NCT03524820 - Cetuximab Therapy for Third Line Rechallenge in Metastatic Colorectal Cancer Phase 2
Active, not recruiting NCT02458664 - BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer N/A
Completed NCT03246438 - Choice Architecture and Colorectal Cancer Screening Outreach N/A
Recruiting NCT04028479 - The Registry of Oncology Outcomes Associated With Testing and Treatment
Not yet recruiting NCT03910283 - Leveraging Mindsets to Improve Health & Wellbeing in Patients With Cancer N/A
Completed NCT03928678 - Implementation of Enhanced Recovery After Surgery Program (ERAS) in Colorectal Cancer Surgery, a Randomized Controlled Trial N/A
Completed NCT03546569 - Tumor Cells, Tumor DNA and Immunological Response in Colonic Stent Placement
Recruiting NCT03896958 - The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
Not yet recruiting NCT06035731 - Evaluation of the Medical Service by Socio-aesthetics in Oncology N/A
Completed NCT04971304 - Comparative Effectiveness Analysis of Granulocyte Colony Stimulating Factor Originator Products Versus Biosimilars
Completed NCT05030090 - Integrative Nutrition Care Plan for the Patient With Liver and Colorectal Cancer N/A
Not yet recruiting NCT04773626 - Tumor Deposits in Cancer Colon
Recruiting NCT05887531 - Abdominopelvic Cancer Prehabilitation N/A
Withdrawn NCT04274790 - Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer
Completed NCT03416777 - Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer N/A
Completed NCT03210129 - Motivational Interviewing to Increase Physical Activity Behaviour in Cancer Patients N/A