Cancer of Breast Clinical Trial
Official title:
Randomized Study on Postmenopausal Women With Early Stage Breast Cancer: Adjuvant Hypofractionated Whole Breast Irradiation (WBI) Versus Accelerated Partial Breast Irradiation (APBI)
Selected patients with early stage breast cancer undergone conservative surgery were randomized in two arms: Hypofractionated Whole Breast Irradiation versus Accelerated Partial Breast Irradiation.
Patients treated with Hypofractionated Whole Breast Irradiation (WBI) received SIB
irradiation of the whole breast and surgical bed at two different dose levels. Dose
prescription was 40.5 Gy to PTVWB and 48.0 Gy to PTVboost in 15 fractions over 3 weeks, with
simultaneous integrated boost delivering 2.7 and 3.2Gy/fraction for each PTV respectively.
Daily image guided radiotherapy (IGRT) were generated before each treatment session in each
patient to verify the set-up.
Accelerated Partial Breast Irradiation (APBI) using external intensity -modulated
radiotherapy (VMAT RA) was delivered at a dose of 30 Gy in five 6-Gy/day fractions over 10
days (every other day) with IGRT at each treatment.
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