A Phase 1 Open-Label Study of E7974 Administered on Days 1 and 15 of a 28-Day Cycle in Patients With Solid Malignancies

Cancer, Malignant Tumors Clinical Trial

Official title:

A Phase 1 Open-Label Study of E7974 Administered on Days 1 and 15 of a 28-Day Cycle in Patients With Solid Malignancies

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00130169
• Other study ID #: E7974-A001-102
• Status: Completed
• Phase: Phase 1
• First received: August 12, 2005
• Last updated: June 29, 2015
• Start date: January 2006
• Est. completion date: August 2009

Study information

• Verified date: June 2015
• Source: Eisai Inc.
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the maximum tolerated dose (MTD) of E7974 administered on Days 1 and 15 of a 28-day cycle in subjects with solid malignancies that have progressed following effective therapy or for which no effective therapy exists.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: August 2009
• Est. primary completion date: August 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Patients who meet all of the inclusion criteria and none of the exclusion criteria will be eligible for entry into the study:

1. Patients must have a pathologically diagnosed, histologically or cytologically confirmed solid malignancy that has progressed following effective therapy or for which no effective therapy exists (including surgery or radiation therapy).

2. Patients must be >= 18 years of age.

3. Patients must have an Eastern Cooperative Oncology Group (ECOG) status of 0, 1 or 2.

4. Patients must have a life expectancy of >= 3 months.

5. Patients must have adequate renal function as evidenced by serum creatinine <= 1.5 mg/dL or creatinine clearance >= 40 mL/minute (min)

6. Patients must have adequate bone marrow function as evidenced by absolute neutrophil count >= 1,200/µL, hemoglobin of >= 9 g/dL (may be transfused), and platelet count (not transfused) >= 100,000/µL.

7. Patients must have adequate liver function as evidenced by bilirubin <= 1.5 mg/dL and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <= 3 times the upper limits of normal (ULN), unless related to liver involvement by tumor, in which case <= 5.0 times ULN.

8. Patients must be willing and able to sign written informed consent and be able to comply with the study protocol for the duration of the study.

9. Patients must be willing and able to undergo blood draw and urine sampling for PK in Cycle 1.

10. Patients may have either measurable or non-measurable disease.

For Prostate Cancer patients only being enrolled at the MTD expansion phase:

1. Males with histologically proven adenocarcinoma of the prostate that has progressed (i.e. a minimum of three successive baseline values to document two consecutive rises in Prostate Specific Antigen (PSA) (with the last value 5 ng/mL) taken at least one week apart prior to study entry) despite castration or maintenance of castrate-level testosterone (defined as serum testosterone 50 ng/dL or 1.7 nmol/L), during non-hormonal chemotherapy.

2. Patients must have failed at least one previous chemotherapeutic regimen with tubulin binding agents such as docetaxel.

Exclusion Criteria:The presence of one or more of the following criteria will disqualify a patient from enrollment in the study:

1. Patients who have received chemotherapy within three weeks of E7974 treatment start (6 weeks for a nitrosourea).

2. Patients who have not recovered from any chemotherapy-related or other therapy-related toxicity to <= Grade 1 at study entry (excluding Grade 2 alopecia).

3. Patients who have received radiotherapy <= 3 weeks prior to study enrollment, whose marrow exposure has exceeded 25% and who have not recovered from the toxic effects of the treatment prior to study enrollment (except for alopecia).

4. Patients who have had major surgery without full recovery or major surgery within three weeks of E7974 treatment start.

5. Patients with primary brain tumors or metastasis at study entry must have controlled them for >= 1 month by previous treatment, including radiation therapy and corticosteroids.

6. Women who are pregnant or breastfeeding.

7. Women of childbearing potential with either a positive serum pregnancy test at screening or no pregnancy test.

8. Women of childbearing potential unless (1) surgically sterile, (2) physiologically postmenopausal for >= 12 months, or (3) using adequate measures (including barrier methods) of contraception.

9. Fertile men or their partners who are not willing to use contraception.

10. Patients who have a history of positive testing for Human Immunodeficiency Virus (HIV) and/or have active hepatitis B or active hepatitis C at study entry.

11. Patients with severe, uncontrolled intercurrent illness or infection.

12. Patients with medically uncontrolled cardiovascular illness defined as unstable angina, >= symptomatic Grade II New York Heart Association (NYHA) Classification congestive heart failure (CHF), or myocardial infarction within six months prior to study entry.

13. Patients who have received organ allografts requiring immunosuppressive therapy.

14. Patients who have received investigational drugs including immunotherapy, gene therapy, hormone therapy, biologic therapy, or chemotherapy within the three-week period prior to E7974 treatment start; patients must have recovered from any previous major therapy-related toxicities (Grade 3 or 4) to <= Grade 1 at study entry (excluding Grade 2 alopecia).

15. Patients with a current history of peripheral neuropathy > CTC Grade 1 (e.g., diabetic or chemotherapy-induced neuropathy).

16. Patients with a history of uncontrolled seizures.

17. Patients with marked baseline prolongation of QT/QTc interval (QTc interval >470) using the Fridericia method as the main method of QTc analysis.

18. Patients with other significant diseases or disorders that, in the Investigator's opinion, would exclude them from the study.

19. Patients with allergy or hypersensitivity to hemiasterlin based product or analogue.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Cancer, Malignant Tumors
• Neoplasms

Intervention

Drug:
• E7974
Maximum Tolerated Dose defined as 0.35 mg/m^2 administered on Days 1 and 15 only of a 28-day cycle; the E7974 compound is administered as a bolus infusion; no placebo is given.

Locations

Country	Name	City	State
United States	Nevada Cancer Institute	Las Vegas	Nevada
United States	University Hospital Medical Center - SUNY at Stony Brook	Stony Brook	New York

Sponsors (1)

Lead Sponsor	Collaborator
Eisai Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Determine the maximum tolerated dose of E7974 in patients with solid malignancies.		Duration of each cycle will be 28 days; patients will attend a follow-up visit 30 days after last study treatment. Follow-up for safety and efficacy will occur 6 months after the last patient is accrued to the study.	Yes
Secondary	Assess E7974 for safety, efficacy, pharmacokinetics and pharmacodynamics; evaluate the efficacy of E7974 in patients with metastatic, refractory prostate cancer.		Duration of each cycle will be 28 days; patients will attend a follow-up visit 30 days after last study treatment. Follow-up for safety and efficacy will occur 6 months after the last patient is accrued to the study.	Yes