Irritable Bowel Syndrome Clinical Trial
Official title:
An Observational Study of the Role of Antibiotics, Inflammation and Changes in Microbiota in the Development of Post-infective Bowel Dysfunction Following Infection With Campylobacter Jejuni or Coli
The principal research objective is to determine the impact of antibiotic use on the risk of developing long term bowel symptoms after infection with the germ Campylobacter.
The secondary research objectives are:
- To investigate how the particular strain of the Campylobacter germ that causes the
infection, and the strength of the immune response that it stimulates in the bowel,
affect the risk of long term bowel symptoms.
- To explore what changes occur after Campylobacter infection in the bacteria that
usually live in the large bowel (microbiota) and the chemicals that they produce
(short-chain fatty acids) when they digest nutrients. We will look for differences
between people who recover fully and people who have long term bowel symptoms.
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