Caffeine and Training Intensity Quantification

Caffeine Clinical Trial

Official title:

The Effects of Caffeine Supplementation on Training Intensity Quantification

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06210984
• Other study ID #: Stmarys1
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 31, 2024
• Est. completion date: December 31, 2025

Study information

• Verified date: January 2024
• Source: St. Mary's University, Twickenham
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to learn about the effects of caffeine on exercise physiology and the subsequent quantification of athlete training zones in trained cyclists. The main questions that it aims to answer are:

• What are the effects of low and moderate doses of caffeine on exercise physiology.

• How do the effects of caffeine on exercise physiology affect the calculation of training zones.

• Do the effects of caffeine on exercise physiology differ between men and women.

Participants will complete four trials on a cycle ergometer as follows:

• Trial 1: participants will complete two incremental tests to determine the power outputs required to elicit 50-80% of maximal oxygen consumption for trials 2-4.

• Trials 2-4: participants will consume (in a randomized order) either a low (2 mg/kg) dose of caffeine, a moderate (5 mg/kg) dose of caffeine, or a placebo (maltodextrin), 45 minutes prior to to completing an incremental cycling test from 50-80% of maximal oxygen uptake.

Measures of heart rate, oxygen uptake, blood lactate, and perceived exertion will be recorded throughout all trials.

Researchers will compare the effects of exercise intensity, caffeine dose, and sex to see if they affect exercise physiology and training zone quantification.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 36
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• To be considered for inclusion in the study, participants must be regular cyclists, between 18 and 45 years of age, capable of completing a 20 km cycling time trial at a minimum speed of 30 km/h for men and 28 km/h for women (arbitrary inclusion criteria to ensure a sufficient standard of athlete). Female participants must have a regular menstrual cycle and not be taking oral contraceptives.

Exclusion Criteria:

-

Related Conditions & MeSH terms

• Caffeine

Intervention

Drug:
• Low caffeine dose
2 mg/kg dose of caffeine in pill form
• Moderate caffeine dose
5 mg/kg dose of caffeine in pill form
• Placebo
5 mg/kg dose of maltodextrin in pill form

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
St. Mary's University, Twickenham

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood lactate concentration	Change from baseline in blood lactate concentration measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	From baseline to completion, up to 31 days
Primary	Heart rate	Change from baseline in heart rate measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	From baseline to completion, up to 31 days
Primary	Oxygen uptake	Change from baseline in oxygen uptake measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	From baseline to completion, up to 31 days
Primary	Perceived exertion	Change from baseline in rating of perceived exertion measured (using the 6-20 Borg scale) at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer	From baseline to completion, up to 31 days