Caffeine Clinical Trial
Official title:
Influence of the Genetic Polymorphisms in the Effect of Caffeine on Fat Oxidation During Exercise
Verified date | July 2022 |
Source | Universidad Francisco de Vitoria |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Genetic polymorphism on the effect of oral caffeine intake on fat oxidation during exercise has been studied in active and healthy population performing an incremental test on a cycle ergometer with 3-min stages at workloads from 30 to 70% of maximal oxygen uptake (VO2max). Participants performed this test after the ingestion of a) placebo; b) 3 mg/kg of caffeine; c) 6 mg/kg of caffeine. Fat oxidation rate during exercise was measured by indirect calorimetry. The influence of the CYP1A2 c.-163A>C, GSTP c.313A>G and PGC1a polymorphisms was evaluated to determine the effects on fat oxidation during exercise
Status | Completed |
Enrollment | 32 |
Est. completion date | April 1, 2022 |
Est. primary completion date | February 10, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: To be non-smokers. To have low caffeine intake (i.e., < 50 mg of caffeine per day in the previous 2 months) To show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months. Exclusion Criteria: To have VO2max values below 40 ml/kg/min To be sedentary |
Country | Name | City | State |
---|---|---|---|
Spain | Universidad Francisco de Vitoria | Pozuelo De Alarcón | Madrid |
Lead Sponsor | Collaborator |
---|---|
Universidad Francisco de Vitoria |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Genotype frequency of CYP1A2 polymorphism | Samples shall be obtained by swabbing and scraping of the buccal mucosa by the participant. The c.-163A>C (rs762551) polymorphism will be used. | Baseline | |
Primary | Genotype frequency of GSTP polymorphism | Samples shall be obtained by swabbing and scraping of the buccal mucosa by the participant. The c.1444G>A (rs8192678) and C>T (rs17650401) polymorphisms will be used. | Baseline | |
Primary | Genotype frequency of PGC1a polymorphisms | Samples shall be obtained by swabbing and scraping of the buccal mucosa by the participant. The c.313A>G (rs1695) polymorphism will be used. | Baseline | |
Secondary | FATmax | The intensity of exercise that elicits MFO | 2-months | |
Secondary | MFO | Maximal fat oxidation during exercise | 2-months | |
Secondary | RPE | Rate of percevied exertion during exercise | 2-months | |
Secondary | FAT and CHO oxidation | Fat and carbohydrates oxidation | 2-months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT06038903 -
The Turkish Version Of The Brief-Caffeine Expectancy Questionnaire
|
||
Completed |
NCT02900261 -
Study on Sodium and Caffeine in Children and Adolescents
|
||
Completed |
NCT03850275 -
The Effects of e+Shots Energy Beverage on Mental Energy
|
N/A | |
Completed |
NCT01924481 -
Effects of a Cocoa Shot on the Human Brain
|
N/A | |
Completed |
NCT01330680 -
Genetic Determinants of Cardiovascular Response to Coffee Drinking
|
N/A | |
Completed |
NCT00184912 -
The Effect of Caffeine on Ischemic Preconditioning
|
N/A | |
Completed |
NCT03859882 -
Protocol PERCAF 2018
|
N/A | |
Completed |
NCT02832401 -
The Impact of Caffeine on Cognition in Schizophrenia
|
N/A | |
Completed |
NCT04560595 -
Remote Guided Caffeine Reduction
|
N/A | |
Recruiting |
NCT05503732 -
Effects of Energy Drinks on Sleep and Cardiovascular Health
|
N/A | |
Not yet recruiting |
NCT05521386 -
The Effects of Caffeine on Heart Rate and Heart Rate Variability
|
N/A | |
Completed |
NCT06039358 -
Effects of Caffeine Ingestion on the Biomechanics of Healthy Young Subjects
|
N/A | |
Active, not recruiting |
NCT04547868 -
Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery
|
N/A | |
Completed |
NCT05559372 -
Energy Drink Effects on Performance, Mood, and Cardiovascular Outcomes
|
N/A | |
Completed |
NCT01783561 -
Early Versus Routine Caffeine Administration in Extremely Preterm Neonates
|
Phase 4 | |
Completed |
NCT04852315 -
Acute Caffeine Ingestion on Futsal Performance
|
N/A | |
Recruiting |
NCT03298347 -
Caffeine for Preterm Infants With Apnea of Prematurity(AOP)
|
N/A | |
Completed |
NCT01435486 -
Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants
|
N/A | |
Completed |
NCT04869176 -
Effect of Caffeine on Heart Rate Variability in Newborns
|
N/A | |
Completed |
NCT04585854 -
Effect of Caffeine on Myocardial Oxygenation
|
N/A |