Caffeine Clinical Trial
Official title:
Direct Effect of Caffeine on Diaphragmatic Muscles
The mechanism of methylxanthines is thought to increase chemoreceptor responsiveness to CO2
in central nervous system. Besides, effect of methylxanthines on diaphragmatic contractility
has also been found in experimental studies. A study of premature newborns has showed
caffeine increase diaphragmatic activity and tidal volume. But, there is limited data about
caffeine direct effect on diaphragma.
Objective: The investigators aimed to show the direct effect of caffeine on diphragmatic
contractility.
Method: The babies under 32 weeks with respiratory support, are being enrolled in this study
if caffeine treatment is decided to receive. Evaluation of muscle contraction is being made
by ultrasound before and 30 minutes after caffeine loading dose. Right and left sides of
diaphragm thickness are being measured by two clinicians on B mode ultrasound by anterior
subcostal view. The velocity before and after caffeine administration will be calculated,
dividing excursion frequency (parameter) for inspiratory time. Movement of the diaphragm at
inspiratory and expiratory phases are also observed on M mode and the difference between the
two phases are measured.
n/a
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