Effects of a Cocoa Shot on the Human Brain

Status Completed

Clinical Trial Summary

The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function. The main substances in the drinks that are known to influence the brain are caffeine (and related chemicals such as theobromine) and flavonoids. Flavonoids are chemical found in plants and are most commonly associated with antioxidant activity. Caffeine, chemicals related to caffeine, and flavonoids are all naturally occurring and all potentially alter brain physiology. This study will evaluate changes in brain blood flow and cognition following the consumption of drinks with various combinations of the Primary Ingredients. Caffeine is likely to have peak effects within 1-hour of ingesting the chocolate while the flavonoids are likely to have peak effects 3-4 hours after ingestion. The study proposed here will evaluate ingredients in a 4-arm cross-over double-blind design in an attempt to understand the differential effects of these compounds in chocolate drinks.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01924481
Study type	Interventional
Source	Wake Forest University Health Sciences
Contact
Status	Completed
Phase	N/A
Start date	September 2013
Completion date	October 2013

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT06038903` - The Turkish Version Of The Brief-Caffeine Expectancy Questionnaire
Completed	`NCT02900261` - Study on Sodium and Caffeine in Children and Adolescents
Completed	`NCT03850275` - The Effects of e+Shots Energy Beverage on Mental Energy	N/A
Completed	`NCT01330680` - Genetic Determinants of Cardiovascular Response to Coffee Drinking	N/A
Completed	`NCT00184912` - The Effect of Caffeine on Ischemic Preconditioning	N/A
Completed	`NCT03859882` - Protocol PERCAF 2018	N/A
Completed	`NCT02832401` - The Impact of Caffeine on Cognition in Schizophrenia	N/A
Completed	`NCT04560595` - Remote Guided Caffeine Reduction	N/A
Recruiting	`NCT05503732` - Effects of Energy Drinks on Sleep and Cardiovascular Health	N/A
Not yet recruiting	`NCT05521386` - The Effects of Caffeine on Heart Rate and Heart Rate Variability	N/A
Completed	`NCT06039358` - Effects of Caffeine Ingestion on the Biomechanics of Healthy Young Subjects	N/A
Active, not recruiting	`NCT04547868` - Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery	N/A
Completed	`NCT05559372` - Energy Drink Effects on Performance, Mood, and Cardiovascular Outcomes	N/A
Completed	`NCT01783561` - Early Versus Routine Caffeine Administration in Extremely Preterm Neonates	Phase 4
Completed	`NCT04852315` - Acute Caffeine Ingestion on Futsal Performance	N/A
Completed	`NCT05975489` - Genetics in the Effect of Caffeine on Fat Oxidation	N/A
Recruiting	`NCT03298347` - Caffeine for Preterm Infants With Apnea of Prematurity(AOP)	N/A
Completed	`NCT01435486` - Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants	N/A
Completed	`NCT04869176` - Effect of Caffeine on Heart Rate Variability in Newborns	N/A
Completed	`NCT04585854` - Effect of Caffeine on Myocardial Oxygenation	N/A