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NCT02071784 Clinical Trial

Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

CADASIL Clinical Trial

— MACOUPLING-CAD  

Official title:
Etude Comparative en Imagerie Par résonnance magnétique et Par Enregistrement électroencéphalographique du Couplage Neurovasculaire Dans l'Angiopathie Cadasil

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02071784
Other study ID # C13-62
Secondary ID 2014-A00200-47
Status Completed
Phase
First received
Last updated
Start date July 8, 2014
Est. completion date October 24, 2016

Study information
Verified date August 2021
Source Institut National de la Santé Et de la Recherche Médicale, France
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.

Description:

Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date October 24, 2016
Est. primary completion date October 24, 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance Exclusion Criteria: - MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
France CENIR, Hopital Pitié Salpetriere Paris

Sponsors (1)
Lead Sponsor Collaborator
Institut National de la Santé Et de la Recherche Médicale, France

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary model-derived parameters of neurovascular coupling one time point
See also
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