Burning Mouth Syndrome Clinical Trial
Official title:
Burning Mouth Disorder (BMD) - a Neuropathic Pain Disorder? An Investigation Using Qualitative and Quantitative Sensory Testing (QST)
Oral burning can have a multitude of reasons. Recent neurophysiologic study results suggest that a primary burning mouth disorder (BMD) may be a peripheral and/or a central neuropathic disorder. The aim of this study is to first identify patients with a primary burning mouth disorder by excluding other possible causes for oral burning. By means of qualitative and quantitative sensory testing and a gustatory examination in the individual patient the investigators want to find out whether neurosensory differences exist between patients with a primary BMD and controls and whether gustatory and neurosensory deficits always coexist in BMD-patients.
Status | Recruiting |
Enrollment | 12 |
Est. completion date | December 2013 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Primary burning sensation of the tongue, lip or other oral structure - Average pain intensity between 3 and 9 (VAS-Scale 0-10) - Written, informed consent - patient speaks German - Age > 18 years old Exclusion Criteria: - Tumor - HIV/AIDS - Diabetes mellitus - untreated hypothyroidism - gastroesophageal reflux disease - Sjögren's disease - Salivary gland disease - Vitamin B-, folic acid- and iron deficiency - Medications causing hyposalivation - Inflammatory, viral, bacterial, fungal, autoimmune and other diseases of the oral mucosa - Insufficient prosthodontics - Allergy against acrylic resin of prosthesis - Allergy against Chinin-hydrochloride - Xerostomia - Pregnancy - Psychiatric disorder |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Germany | Charité - Universitätsmedizin Berlin, Center for dental and craniofacial sciences, Department of restorative dentistry | Berlin |
Lead Sponsor | Collaborator |
---|---|
Markus R. Fussnegger | Deutsche Gesellschaft für Zahn-, Mund- und Kieferheilkunde e.V. |
Germany,
Bartoshuk LM, Snyder DJ, Grushka M, Berger AM, Duffy VB, Kveton JF. Taste damage: previously unsuspected consequences. Chem Senses. 2005 Jan;30 Suppl 1:i218-9. — View Citation
Formaker BK, Frank ME. Taste function in patients with oral burning. Chem Senses. 2000 Oct;25(5):575-81. — View Citation
Forssell H, Jääskeläinen S, Tenovuo O, Hinkka S. Sensory dysfunction in burning mouth syndrome. Pain. 2002 Sep;99(1-2):41-7. — View Citation
Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome and other oral sensory disorders: a unifying hypothesis. Pain Res Manag. 2003 Fall;8(3):133-5. Review. — View Citation
Lauria G, Majorana A, Borgna M, Lombardi R, Penza P, Padovani A, Sapelli P. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. Pain. 2005 Jun;115(3):332-7. — View Citation
Scala A, Checchi L, Montevecchi M, Marini I, Giamberardino MA. Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med. 2003;14(4):275-91. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neurosensory differences between Burning Mouth Disorder patients and controls. | The aim of the present study is to identify patients with idiopathic BMD. By way of qualitative and quantitative sensory testing (QST) and gustatory tests we want to find out whether neurosensory differences exist between patients with BMD and controls without any oral burning sensation. | No |
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