Inflammation Clinical Trial
Official title:
Innate Immune Response in COPD
The purpose of this study is to determine whether the response of the immune system to bacterial components differs between patients with severe COPD compared to those with less severe COPD.
The airways of COPD patients are often colonized with bacteria leading to increased airway
inflammation. This study sought to determine whether systemic cytokine responses to
microbial pathogen-associated molecular patterns (PAMPs) are increased among subjects with
severe COPD.
In an observational cross-sectional study of COPD subjects, PAMP-induced cytokine responses
were measured in whole blood ex vivo. We used PAMPs derived from microbial products
recognized by TLR 1, 2, 4, 5, 6, 7, and 8. Patterns of cytokine response to PAMPs were
assessed using hierarchical clustering. One-sided t-tests were used to compare PAMP-induced
cytokine levels in blood from patients with and without severe COPD, and for subjects with
and without chronic bronchitis.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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