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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT06459895
Other study ID # Soh-Med-24-05-03PD
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 16, 2024
Est. completion date June 10, 2024

Study information

Verified date June 2024
Source Sohag University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Bronchial asthma affects more than a quarter of a billion people worldwide. It is responsible for over 1000 deaths a day, of which the majority are preventable (Levy, 2015). Asthma is a common heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of variable respiratory symptoms, such as shortness of breath, chest tightness, wheezes, and cough, together with variable expiratory airflow limitation. Airflow limitation may later become persistent (GINA, 2023). The diagnosis of asthma is based on the history of these characteristic symptoms and evidence of variable expiratory airflow limitation from bronchodilator reversibility testing or other tests (GINA, 2023).


Recruitment information / eligibility

Status Completed
Enrollment 194
Est. completion date June 10, 2024
Est. primary completion date June 10, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 15 Years to 50 Years
Eligibility Inclusion Criteria: - All patients were admitted to Sohag University Hospital, chest department DIAGNOSED AS BRONCHIAL ASTHMA Exclusion Criteria: - Patients with malignancies, major trauma or surgery, and acute or chronic infectious diseases were excluded.

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
Long non-coding MALAT1 gene expression assay:
RNA extraction (isolation from whole blood) II-Synthesis of CDNA from RNA by reverse transcription III-Gene expression assay by RT-PCR reaction

Locations

Country Name City State
Egypt Sohag University Hospital Sohag

Sponsors (1)

Lead Sponsor Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (3)

Choi JP, Kim YS, Kim OY, Kim YM, Jeon SG, Roh TY, Park JS, Gho YS, Kim YK. TNF-alpha is a key mediator in the development of Th2 cell response to inhaled allergens induced by a viral PAMP double-stranded RNA. Allergy. 2012 Sep;67(9):1138-48. doi: 10.1111/j.1398-9995.2012.02871.x. Epub 2012 Jul 5. — View Citation

Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004 Oct;10(10):1095-103. doi: 10.1038/nm1105. Epub 2004 Sep 19. — View Citation

Levy ML. The national review of asthma deaths: what did we learn and what needs to change? Breathe (Sheff). 2015 Mar;11(1):14-24. doi: 10.1183/20734735.008914. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Long non-coding MALAT1 gene expression assay: Gene expression assay by RT-PCR reaction 2 MONTHS
Secondary TNF-alpha measured in serum by ELISA 2 MONTHS
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