Study of Efficacy of Gabapentin in Therapy of Bronchial Asthma

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether antiepileptic drug gabapentin is effective in the treatment of chronic asthma.

Clinical Trial Description

Effective therapy of asthma still remains quite serious problem. According GINA definition, asthma is an inflammatory disorder. Consequently, modern pharmacotherapy of asthma provides wide use of anti-inflammatory drugs. But asthma also is a paroxysmal disorder: many specialists and even some guidelines underline paroxysmal clinical picture of asthma. Besides this, according to some authors, neurogenic inflammation may play important role in asthma mechanism. But some other neurogenic inflammatory paroxysmal disorders exist, and they are migraine and trigeminal neuralgia. Some antiepileptic drugs, like carbamazepine and valproate, are very effective in therapy of migraine and trigeminal neuralgia - more than in 80% of cases. If bronchial asthma also is paroxysmal inflammatory disease, like migraine and trigeminal neuralgia, it is possible that some antiepileptic drugs also are very effective in asthma therapy.

We performed a double-blind, placebo-controlled 3-month trial for evaluation of gabapentin efficacy in therapy of bronchial asthma. Gabapentin is antiepileptic drug of new generation, produced by Pfizer.

Comparison: Patients received investigational drug in addition to their usual routine antiasthmatic treatment, compared to patients received placebo in addition to their usual routine antiasthmatic treatment. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00153283
Study type	Interventional
Source	Centre of Chinese Medicine, Georgia
Contact
Status	Completed
Phase	Phase 4
Start date	September 2003
Completion date	April 2004

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02934945` - Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients	Phase 4
Completed	`NCT02561351` - Correlation Between Fractional Exhaled Nitric Oxide (FeNO) Levels and Asthma Exacerbation	N/A
Recruiting	`NCT01759472` - Effect Study of Montelukast to Treat Asthma Detected by LTD4 Bronchial Effect Study of Montelukast to Treat Asthma Detected by LTD4 Bronchial Provocation Test	N/A
Completed	`NCT01918293` - Self-Management Using Smartphone Application for Chronic Disease Care in Real siTuation (SMART-Asthma): Adult	N/A
Completed	`NCT01203904` - Pulmicort Turbuhaler 100/200 Specific Clinical Experience Investigation	N/A
Completed	`NCT01762917` - Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing	N/A
Completed	`NCT00536731` - Symbicort Rapihaler Therapeutic Equivalence Study	Phase 3
Completed	`NCT00930826` - Childhood Asthma and Schooling: The Truth Unveiled	N/A
Completed	`NCT00331929` - Respiratory Health Study of Children in Kiryat Tivon	N/A
Completed	`NCT00327028` - Study of Efficacy of Phenytoin in Therapy of Patients With Bronchial Asthma	Phase 4
Completed	`NCT00413387` - Efficacy and Tolerability of Beclomethasone Dipropionate 100 µg + Formoterol 6 µg pMDI Via HFA-134a Vs. Budesonide 160 µg + Formoterol 4,5 µg Dry Powder Via Turbuhaler®. (Symbicort®)	Phase 3
Completed	`NCT00950794` - Study of Salmeterol (SN408D) for Adult Asthma	Phase 4
Completed	`NCT00142025` - Study of Efficacy of Oxcarbazepine in Therapy of Bronchial Asthma	Phase 4
Completed	`NCT00153270` - Study of Efficacy of Sodium Valproate in Therapy of Bronchial Asthma	Phase 4
Completed	`NCT03450434` - XC8 in the Treatment of Patients With Bronchial Asthma	Phase 2
Recruiting	`NCT05189613` - Mepolizumab Effectiveness in Severe Eosinophilic Asthma and Bronchiectasis	N/A
Recruiting	`NCT04128111` - Study on the Correlation Between TCM Syndrome, Inflammatory Phenotype and Biomarker of Bronchial Asthma
Completed	`NCT06326632` - Comparative Effectiveness Study of Constant-Load Versus Graded Aerobic Exercise in Obese Children With Bronchial Asthma	N/A
Completed	`NCT05088512` - The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population
Completed	`NCT01232322` - Pulmicort Respules 0.25/0.5 Specific Clinical Experience Investigation	N/A