Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06331897 |
| Other study ID # |
Bronchial asthma |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2025 |
| Est. completion date |
June 1, 2026 |
Study information
| Verified date |
March 2024 |
| Source |
Assiut University |
| Contact |
Mohamed ragab kamel, resident pediatrician |
| Phone |
+20 109 610 6605 |
| Email |
ibnragab34[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
Our goals is to assess :
1¬_ the role of spirometer in case of asthma exacerbation 2_hematological parameters (N/L
ratio & platelet indices &CRP )in asthma exacerbation for diagnosing and classifying
asthma severity and its exacerbation
Description:
Bronchial asthma is a chronic inflammatory disease characterized by bronchial
hyper-reactivity, reversible airway obstruction, and excessive mucus production that arises
from an inappropriate stimulation of the immune system, especially by environmental
aeroallergens .Bronchial asthma exacerbations are episodes described by progressive increase
in symptoms of cough, wheezing, shortness of breath, and/or chest tightness, with a
progressive decrease in lung function . Few tests are being used for diagnosis of asthma, but
at present, no established biomarker is available that may be used for diagnosis and
prognosis of asthma . Platelet indices and C-reactive protein (CRP) are markers that reflect
a systemic inflammatory response . Bronchial obstruction, variable over time and reversible
after using bronchodilator is the hallmark of the respiratory function in bronchial asthma.
There are patients with "atypical" functional tests or in whom routine tests
(spirometry, peak-flowmetry) are not sufficient for asthma diagnosis (thus necessitating more
complex functional tests). Pulmonary function evaluation confirms the diagnostic, establishes
disease severity and contributes to disease monitoring. Quality criteria verification (e.g.
acceptability of the measurements and reproducibility of the parameters) should precede any
interpretation . Neutrophilic, eosinophilic, paucigranulocytic or mixed granulocytic types
are four various endotypes of asthma [6] depending on cell counts of peripheral blood .
Neutrophilic inflammations have been studied to be associated with a poor asthma control . In
addition to persistent asthma symptoms and atopy, they have been reported to be associated
with the presence of eosinophilic inflammation in asthmatic patients . Accordingly, NLR
increase in asthmatics was considered. However, data related to NLR in Asthmatic patients is
inadequate . Though association between asthma and NLR, was discovered by earlier researches
in adults, recent researches did not study NLR relation to neutrophilic asthma . So, we aimed
to assess the relation of NLR and bronchial asthma severity and to determine NLR
discriminative performance between controlled and uncontrolled asthma . Platelet indices,
which include the mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit
(PCT), and platelet large cell correlated with white blood cells, PaO2, and symptoms
duration, and negatively correlated with forced expiratory volume in the first second,
symptoms duration, and hs-CRP (P<0.001).
Higher autophagy of neutrophils has been described in many pulmonary disorders as well as
neutrophil extracellular traps and exosomes that has been newly studied as deriving from
neutrophil . So neutrophils role in pulmonary diseases have been established. Despite
pulmonary diseases pathogeneses are being studied widely, there is still more and more to get
clarification of the discrepancy and complexity, particularly the contribution of different
immune mechanisms in the progress of pulmonary disorders .
