The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population

Bronchial Asthma Clinical Trial

Official title:

Preventive and Personalized Medicine (2021-2023)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05088512
• Other study ID #: 1207
• Status: Completed
• Start date: October 23, 2021
• Est. completion date: January 20, 2023

Study information

• Verified date: March 2023
• Source: Asfendiyarov Kazakh National Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.

Description:

Unrelated Kazaks subjects who have bronchial asthma were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with bronchial asthma and normal control subjects free of bronchial asthma

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: January 20, 2023
• Est. primary completion date: January 20, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 65 Years

Eligibility

Inclusion Criteria:

• Persons with bronchial asthma confirmed by a doctor;
• The age of the patients is from 5 to 60 years;
• Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
• Persons who are able and willing to provide written informed consent;
• Persons capable and willing to comply with the research protocol;

Exclusion Criteria:

• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Oncological diseases;

Related Conditions & MeSH terms

• Asthma
• Bronchial Asthma

Intervention

Genetic:
• SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Locations

Country	Name	City	State
Kazakhstan	Kazakhstan	Almaty

Sponsors (1)

Lead Sponsor	Collaborator
Asfendiyarov Kazakh National Medical University

Country where clinical trial is conducted

Kazakhstan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	number of SNPs associated with bronchial asthma	Using SNPsto identify candidate genes associate with bronchial asthma	1 year