Bronchial Asthma Clinical Trial
Official title:
Treatment of Bronchial Asthma With Borage and Echium Seed Oils
The aim of this trial is to determine the efficacy of a combination of two botanicals oils, borage seed oil and echium seed oil, as a potential treatment for bronchial asthma.
Leukotrienes are important in the pathogenesis of inflammation, and leukotriene modifying
drugs are now an established treatment for bronchial asthma and rhinitis. Drugs that inhibit
the biosynthesis of leukotrienes are likely to be more effective than the currently
available drugs that antagonize a single leukotriene receptor. Dietary supplementation with
gamma linolenic acid (GLA) in borage seed oil provides effective inhibition of leukotriene
generation but also increases circulating free arachidonic acid (AA), which has
pro-inflammatory potential. The n-3 fatty acid, eicosapentaenoic acid (EPA), prevented the
conversion of GLA to AA. However, EPA is extracted from fish oil, is not well-tolerated due
to its taste, and at higher doses appeared to blunt the inhibition of leukotriene
biosynthesis by GLA. Stearidonic acid (SDA) is a precursor of EPA that is extracted from
Echium plantagineum; it is converted to EPA in humans and it does not have the organoleptic
properties of EPA.
We recently completed a dose-ranging study in which we determined the dose of SDA that is
sufficient to inhibit the rise in circulating levels of arachidonic acid while maintaining
effective inhibition of leukotriene generation.
The goal of the present study is to test the efficacy of dietary supplementation with GLA
and SDA (provided in borage seed oil and echium seed oil) in treating bronchial asthma.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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