Optimizing Body Composition & Health After Breast Cancer

Status Completed

Clinical Trial Summary

The purpose of this study is to conduct a 12-month randomized controlled trial comparing the effects of strength training exercise to stretching and relaxation exercise (control) on body composition (bone, muscle and fat mass), energy balance, bone turnover, and physical function (strength, power, gait, balance and self-report physical function and symptoms) in women who experienced premature menopause from chemotherapy for breast cancer.

Clinical Trial Description

As a result of treatment, breast cancer survivors typically experience unhealthy changes in body composition (bone, muscle and fat). Treatments disrupt normal bone and energy balance resulting in bone and muscle wasting and fat gain. Premenopausal women are at greatest risk for these declines because most are thrust into early menopause from chemotherapy. Hormone manipulation therapy (i.e., tamoxifen or arimidex) may further affect these tissues. Exercise can prevent bone and muscle loss and promote fat loss. However, the ability of exercise to reverse unfavorable changes in all components of body composition in women experiencing early menopause from breast cancer treatment has not been specifically studied. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00659906
Study type	Interventional
Source	OHSU Knight Cancer Institute
Contact
Status	Completed
Phase	N/A
Start date	January 2006
Completion date	January 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03273426` - Prediction of pCR by Preoperative Biopsy in Breast Cancer With cCR After Neoadjuvant Chemotherapy.	N/A
Recruiting	`NCT04583124` - Adjusting the Dose of Therapeutic Exercise to Prevent Neurotoxicity Due to Anticancer Treatment (ATENTO)	N/A
Active, not recruiting	`NCT04489173` - TAS102 in Patients With ER-positive, HER2-negative Advanced Breast Cancer	Phase 2
Recruiting	`NCT02913573` - Effect of Pectoral Nerve Block on Post-op Pain in Patients Undergoing Mastectomy and Immediate Reconstruction	Phase 2
Completed	`NCT03124095` - Combined Training Intervention for Women Who Underwent Primary Treatment for Breast Cancer	N/A
Terminated	`NCT00251095` - Comparison of Safety and Efficacy of TOCOSOL(R) Paclitaxel Versus Taxol(R) for Treatment of Metastatic Breast Cancer	Phase 3
Completed	`NCT05576545` - Develop and Evaluate the Effectiveness of a Self-Care Smartphone Application on the Self-Efficacy, and Resilience Among Newly Diagnosed Breast Cancer Patients Undergoing Treatment	N/A
Active, not recruiting	`NCT03625635` - Effect of a Clinical Nutrition Intervention Program in Breast Cancer Patients During Antineoplastic Treatment	N/A
Recruiting	`NCT04799535` - Quantitative Microvasculature Imaging for Breast Cancer Detection and Monitoring
Withdrawn	`NCT03266562` - Estrogen Receptor Expression in Breast Cancer - Assessed With Positron Emission Mammography	N/A
Completed	`NCT00530868` - Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer	Phase 2
Recruiting	`NCT06255808` - Development of Assist Tool for Breast Examination Using the Principle of Ultrasonic Sensor
Completed	`NCT04640220` - Improvement of Range of Motion in Frozen Shoulder in Breast Cancer Survivors	N/A
Completed	`NCT02970682` - SFX-01 in the Treatment and Evaluation of Metastatic Breast Cancer	Phase 2
Completed	`NCT02316561` - Single Dose Ablative Radiation Treatment for Early-Stage Breast Cancer	N/A
Terminated	`NCT00638963` - Temozolomide as a Prophylaxis Against Brain Recurrence in Participants With Metastatic Breast Cancer (P05225 AM2)	Phase 2
Terminated	`NCT00249301` - A Study of MLN8054 in Patients With Advanced Solid Tumors	Phase 1
Not yet recruiting	`NCT06056414` - Study of Anxiety After a Session of Energy Resonance by Cutaneous Stimulation	N/A
Recruiting	`NCT05427071` - Magnetic Marker Localization for Occult Breast Cancer and Target Axillary Dissection in Node-positive Breast Cancer Post-neoadjuvant Chemotherapy	N/A
Recruiting	`NCT03740893` - PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition and/or Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Chemotherapy Resistant Residual Triple Negative Breast Cancer	Phase 2