Radiation Toxicity Clinical Trial
Official title:
Relationships Between the Changes of Skin Temperature and Radiation Skin Injury
the main purpose of the present study was threefold: (1) to describe the thermographic response after radiation; (2) to investigate whether there was a significant temperature change over time and among the different radiation-dermatitis score; and (3) to test if temperature change could be used to predict the development of radiation-induced skin injury in the incipient stage.
Radiation skin injury (RSI) is a frequent adverse reaction reported encountered by patients
undergoing radiotherapy, occurring in about 87%-95% of irradiated patients and is
characterized by swelling, redness, pigmentation, ulceration, fibrosis, pain, warmth, burning
and itching of the skin. RSI has an effect on the level of discomfort experienced and the
quality of life of patients, and may require interfering with radiation schedule and complex
surgical reconstruction especially when combined with molecular targeted therapy. However,
evaluation of RSI is not straightforward. There is no standard instrument for objective
clinical evaluation of the severity of radiation skin injury.
Previous studies have shown that radiation leads to the development of cutaneous vasculature
and generation of an inflammatory response, which will increased skin temperature. The skin
temperature change due to laser or thermal injury has been measured in many studies with
temperature and time as predictors of skin damage.
The most frequent method of skin temperature measurement has been the Infrared thermography.
Consequently, the changes in the difference of skin temperature (DST) may be used as an
objective, quantitative, and functional surrogate measure to determine and predict RSI.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04059809 -
Photobiomodulation for Breast Cancer Radiodermatitis
|
Phase 2/Phase 3 | |
| Recruiting |
NCT03876860 -
An Enhanced Vaginal Dilator to Reduce Radiation-Induced Vaginal Stenosis
|
N/A | |
| Completed |
NCT02058550 -
Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy
|
Phase 1 | |
| Completed |
NCT01399372 -
Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma
|
Phase 2 | |
| Completed |
NCT01434290 -
Radiation Therapy in Treating Patients With Prostate Cancer
|
Phase 2 | |
| Active, not recruiting |
NCT00087815 -
Hyperbaric Oxygen Therapy in Treating Patients With Radiation Necrosis of the Brain
|
N/A | |
| Completed |
NCT01407770 -
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
|
||
| Completed |
NCT00003313 -
Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer
|
Phase 3 | |
| Completed |
NCT03783364 -
Pre- or Postoperative Accelerated Radiotherapy
|
N/A | |
| Enrolling by invitation |
NCT04305613 -
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
|
||
| Recruiting |
NCT06036706 -
Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:
|
N/A | |
| Withdrawn |
NCT04593914 -
A Novel Skin Barrier Protectant for Acute Radiodermatitis
|
N/A | |
| Recruiting |
NCT04110223 -
Validation Studies of Biomarkers for Precision Radiation Oncology in Locally Advanced Solid Tumors
|
||
| Active, not recruiting |
NCT02259218 -
Metabolomic and Epigenetic Profiling of Bodyfluids From Lung and Brain Cancer Receiving Radiation Therapy
|
||
| Recruiting |
NCT06073509 -
Atrial Fibrillation and Other Cardiac Arrhythmias and Diseases After Radiotherapy for Breast Cancer : Watch Your HeaRT
|
||
| Withdrawn |
NCT02017925 -
Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation
|
N/A | |
| Completed |
NCT01170299 -
Low-Fiber Diet or High-Fiber Diet in Preventing Bowel Side Effects in Patients Undergoing Radiation Therapy for Gynecological Cancer, Bladder Cancer, Colorectal Cancer, or Anal Cancer
|
N/A | |
| Completed |
NCT00974168 -
Spinal Cord Compression Re-Treat Study
|
Phase 2 | |
| Completed |
NCT00008398 -
Sargramostim in Decreasing Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer
|
Phase 3 | |
| Completed |
NCT00004176 -
Amifostine, Chemotherapy, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
|
Phase 2 |