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Clinical Trial Summary

Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.


Clinical Trial Description

A Phase 1, First in Human Study of Adenovirally Transduced Autologous Macrophages Engineered to Contain an Anti-HER2 Chimeric Antigen Receptor in Subjects with HER2 Overexpressing Solid Tumors Main Study - Group 1 and Group 2 all HER2 overexpressing solid tumors Intraperitoneal Substudy - HER2 overexpressing peritoneal disease 89[Zr] radiolabeled CT-0508 Substudy - All HER2 overexpressing solid tumors (Univ of Penn, Abramson Cancer Center only) CT-0508 Combination with Pembrolizumab Substudy - All HER2 overexpressing solid tumors ;


Study Design


Related Conditions & MeSH terms

  • Adenocarcinoma
  • Bile Duct Cancer
  • Bile Duct Neoplasms
  • Biliary Tract Cancer
  • Biliary Tract Neoplasms
  • Bladder Cancer
  • Breast Cancer
  • Breast Neoplasm
  • Breast Neoplasms
  • Cancer
  • Carcinoma
  • Carcinoma, Ductal
  • Carcinoma, Hepatocellular
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Ovarian Epithelial
  • Carcinoma, Small Cell
  • Carcinoma, Squamous
  • Carcinoma, Squamous Cell
  • Carcinoma, Transitional Cell
  • Colorectal Cancer
  • Endometrial Cancer
  • Endometrial Neoplasms
  • Esophagogastric Junction Neoplasms
  • Head and Neck Cancer
  • Head and Neck Neoplasms
  • HER-2 Gene Amplification
  • HER-2 Protein Overexpression
  • HER2-positive
  • HER2-positive Breast Cancer
  • HER2-positive Gastric Cancer
  • HER2-positive Solid Tumors
  • Inflammatory Breast Cancer
  • Lung Cancer, Small Cell
  • Lung Neoplasms
  • Malignant Neoplasms
  • Neoplasms
  • Ovarian Neoplasms
  • Pancreatic Cancer
  • Prostate Cancer
  • Prostatic Neoplasms
  • Small Cell Lung Carcinoma
  • Stomach Neoplasms

NCT number NCT04660929
Study type Interventional
Source Carisma Therapeutics Inc
Contact Ramona Swaby, MD, Vice President - Clinical Development
Phone (610) 427-3494
Email Ramona.Swaby@carismatx.com
Status Recruiting
Phase Phase 1
Start date February 2, 2021
Completion date December 2024

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