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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00392119
Other study ID # NEUROLITT
Secondary ID
Status Completed
Phase Phase 1
First received October 23, 2006
Last updated December 30, 2009
Start date October 2006
Est. completion date December 2008

Study information

Verified date December 2009
Source BioTex, Inc.
Contact n/a
Is FDA regulated No
Health authority France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine if the stereotactic, MR guided, laser interstitial thermal therapy treatment technique can be safety and efficiently used for human brain metastasis and primary brain tumors.


Description:

This new "minimally invasive" technique has been tested so far, with success, on animal brain tumor models and on human liver metastasis.

The main purpose of this study is to determine if the stereotactic, MR guided, laser interstitial thermal therapy treatment technique can be safety and efficiently used for the human brain metastasis and primary brain tumors.

As secondary objectives for this clinical study, the following are to be explored:

- Eventual evaluation of the eventual mid and long term post-intervention complications,

- Evaluate the contra indication for the technique,

- Evaluate and optimize clinical and logistic intervention protocols,

- Evaluate the mean duration for the procedure,

- Evaluate the mean cost for the procedure

The clinical trial will include a statistical sample of 12-18 treatments and will run over a period of 18 months. The inclusion period will be for 6 months and the patients will be followed up during 12 months post intervention.

The clinical trial will be performed at the Lariboisiere University Hospital of Paris and the patients will be coming from all the Assistance Publique de Paris ( APHP ) hospitals


Recruitment information / eligibility

Status Completed
Enrollment 18
Est. completion date December 2008
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients 18 years of age or older

- Patients with brain metastasis located in the brain hemispheres

- Patient with a brain metastasis smaller or equal to 4 cm in diameter

- Patient with primary brain tumor smaller or equal to 4 cm in diameter

- Patient previously treated with other therapeutic techniques ( radio-therapy, chemotherapy, immunotherapy) which have failed.

Exclusion Criteria:

- Patients less than 18 years old,

- Patients presenting contra indication for MRI studies

- Patient for which the primary cancer is melanoma or kidney tumors

- Patients having a mean life duration longer than 3 months (due to the primary cancer)

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Intervention

Device:
MR-guided Laser Interstitial Thermal Therapy System


Locations

Country Name City State
France Hospital Lariboisiere Paris

Sponsors (1)

Lead Sponsor Collaborator
BioTex, Inc.

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary 12 month morbidity and mortality
Secondary Mid and long term post-intervention complications,
Secondary Contra indication for the technique,
Secondary Optimize clinical and logistic intervention protocols,
Secondary Mean procedure duration
Secondary Mean procedure cost
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