Role of MR Spectroscopy in Brain Tumors

Brain Neoplasms Clinical Trial

Official title:

Role of Magnetic Resonance Spectroscopy in Differentiating Brain Tumors

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03619694
• Other study ID #: MRS in brain tumors
• Status: Recruiting
• Start date: September 1, 2017
• Est. completion date: October 1, 2018

Study information

• Verified date: August 2018
• Source: Assiut University
• Contact: Mohamed AbdelWahab, Msc
• Phone: 01148918822
• Email: dr.assiut[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In order to come as close as possible to the correct diagnosis of CNS tumors, MRI is the long-standing accepted method of choice that can in some cases be supported by the use of CT to demonstrate calcification or bone destruction. In individual cases MRI spectroscopy can be helpful for the differentiation between neoplasms and inflammatory lesions or surveillance of tumor therapy, just as perfusion

Description:

Proton magnetic resonance spectroscopy (H-MRS) may be helpful in suggesting tumor histology and tumor grade and may better define tumor extension and the ideal site for biopsy compared with conventional magnetic resonance (MR) imaging. A multifunctional approach with diffusion-weighted imaging, perfusion-weighted imaging, and permeability maps, along with H-MRS, may enhance the accuracy of the diagnosis and characterization of brain tumors and estimation of therapeutic response. Integration of advanced imaging techniques with conventional MR imaging and the clinical history help to improve the accuracy, sensitivity, and specificity in differentiating tumors and nonneoplastic lesions.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: October 1, 2018
• Est. primary completion date: September 1, 2018
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• All patients with space-occupying lesions

Exclusion Criteria:

• Post operative cases

• Non-neoplastic nature

Related Conditions & MeSH terms

• Brain Neoplasms

Intervention

Device:
• MRI Spectroscopy
Patient with brain SOL underwent MRI Spectroscopy to be compared with later pathology

Locations

Country	Name	City	State
Egypt	Assiut University	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (2)

Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ. Brain Tumor Imaging. J Clin Oncol. 2017 Jul 20;35(21):2432-2438. doi: 10.1200/JCO.2017.72.7636. Epub 2017 Jun 22. Review. — View Citation

Peitgen N, Papanagiotou P. [Intra-axial brain tumors in adults : On the basis of the 2016 WHO classification]. Radiologe. 2017 Sep;57(9):707-714. doi: 10.1007/s00117-017-0271-6. Review. German. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of MRS findings with the pathology of the specimens	Analysis of the MRS metabolites peaks and integral and test if they can differentiate the grades of brain tumors	Baseline