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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03619694
Other study ID # MRS in brain tumors
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 1, 2017
Est. completion date October 1, 2018

Study information

Verified date August 2018
Source Assiut University
Contact Mohamed AbdelWahab, Msc
Phone 01148918822
Email dr.assiut@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In order to come as close as possible to the correct diagnosis of CNS tumors, MRI is the long-standing accepted method of choice that can in some cases be supported by the use of CT to demonstrate calcification or bone destruction. In individual cases MRI spectroscopy can be helpful for the differentiation between neoplasms and inflammatory lesions or surveillance of tumor therapy, just as perfusion


Description:

Proton magnetic resonance spectroscopy (H-MRS) may be helpful in suggesting tumor histology and tumor grade and may better define tumor extension and the ideal site for biopsy compared with conventional magnetic resonance (MR) imaging. A multifunctional approach with diffusion-weighted imaging, perfusion-weighted imaging, and permeability maps, along with H-MRS, may enhance the accuracy of the diagnosis and characterization of brain tumors and estimation of therapeutic response. Integration of advanced imaging techniques with conventional MR imaging and the clinical history help to improve the accuracy, sensitivity, and specificity in differentiating tumors and nonneoplastic lesions.


Recruitment information / eligibility

Status Recruiting
Enrollment 100
Est. completion date October 1, 2018
Est. primary completion date September 1, 2018
Accepts healthy volunteers
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

- All patients with space-occupying lesions

Exclusion Criteria:

- Post operative cases

- Non-neoplastic nature

Study Design


Related Conditions & MeSH terms


Intervention

Device:
MRI Spectroscopy
Patient with brain SOL underwent MRI Spectroscopy to be compared with later pathology

Locations

Country Name City State
Egypt Assiut University Assiut

Sponsors (1)

Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (2)

Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ. Brain Tumor Imaging. J Clin Oncol. 2017 Jul 20;35(21):2432-2438. doi: 10.1200/JCO.2017.72.7636. Epub 2017 Jun 22. Review. — View Citation

Peitgen N, Papanagiotou P. [Intra-axial brain tumors in adults : On the basis of the 2016 WHO classification]. Radiologe. 2017 Sep;57(9):707-714. doi: 10.1007/s00117-017-0271-6. Review. German. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Comparison of MRS findings with the pathology of the specimens Analysis of the MRS metabolites peaks and integral and test if they can differentiate the grades of brain tumors Baseline
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