Brain Metastases Clinical Trial
Official title:
High-dose Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases
This phase II trial is studying how well pemetrexed disodium works in treating patients with Lung Adenocarcinoma With Brain Metastases
- Determine the 6-month progression-free survival rate in patients with Lung
Adenocarcinoma With Brain Metastases treated with pemetrexed disodium.
- Determine the time to progression in patients with Lung Adenocarcinoma With Brain
Metastases treated with pemetrexed disodium.
Secondary
- Determine the radiographic response in patients with Lung Adenocarcinoma With Brain
Metastases treated with pemetrexed disodium.
- Determine the time to response in patients treated with this drug.
- Determine the duration of response in patients treated with this drug.
- Determine the overall survival of patients treated with this drug.
- Collect safety data on patients with intracranial tumors treated with this drug.
OUTLINE: Patients receive pemetrexed disodium IV over 10 minutes on day 1. Courses repeat
every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed periodically. PROJECTED ACCRUAL:
A total of 25 patients will be accrued for this study.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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