Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain — HP Brain  

Brain Metabolism Clinical Trial

Official title: Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain

Status Enrolling by invitation

Clinical Trial Summary

Investigators propose to develop hyperpolarized [13C]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.

Clinical Trial Description

Investigators will perform a pilot study to test the translational feasibility by evaluating sensitivity and repeatability of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate in healthy human subjects (n =10 each). Each subject will be imaged twice using the same hyperpolarized substrate with an interval (<45min) between the injections to evaluate repeatability. Finally, eight subjects will be imaged with both hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate for comparison. ;

Related Conditions & MeSH terms

• Brain Metabolism

• NCT number: NCT03849963
• Study type: Observational
• Source: University of Texas Southwestern Medical Center
• Status: Enrolling by invitation
• Start date: July 30, 2020
• Completion date: December 31, 2024