Brain Metabolism Clinical Trial
Official title:
Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study
Verified date | January 2015 |
Source | University of Aarhus |
Contact | n/a |
Is FDA regulated | No |
Health authority | Denmark: Sundhedsstyrelsen |
Study type | Interventional |
This project tend to investigate the affection of ketone bodies on brain metabolism. This
will be done by measuring human cerebral uptake of energy substrates, together with
functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia
in healthy subjects by ketone infusion.
Hypotheses
1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake
by brain cells contributing to hyperglycaemia.
2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood
flow.
3. Altered oxygen consumption during hyperketonemia in healthy subjects.
Status | Completed |
Enrollment | 9 |
Est. completion date | January 2016 |
Est. primary completion date | January 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 50 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Healthy - BMI 20-30 kg/m2 Exclusion Criteria: - smoking - alcohol abuse - severe comorbidity - blood donation 6 month prior - claustrophobia |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Denmark | Aarhus University Hospital | Aarhus |
Lead Sponsor | Collaborator |
---|---|
University of Aarhus |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Glucose metabolism in brain, CMR | cerebral glucose metabolism measured by PET tracer during the above time frame | t=240-360 minutes | No |
Secondary | Stress metabolism | growth hormone, cortisol, glucagon, adrenalin, ghrelin. | 0-360 minutes | No |
Secondary | Oxygen use | cerebral oxygen consumption measured by PET tracer during the above time frame | T=150-200 minutes | No |
Secondary | cerebral blood flow | cerebral blood flow measured by PET tracer during the above time frame | t=180-250 minutes | No |
Secondary | Intramuscular signaling | protein and insulin signaling in muscle | t= 260 minutes | No |
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---|---|---|---|
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