Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study

Brain Metabolism Clinical Trial

Official title: Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study

Status Completed

Clinical Trial Summary

This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.

Hypotheses

1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.

2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.

3. Altered oxygen consumption during hyperketonemia in healthy subjects.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Brain Metabolism
• Ketone Body Metabolism

• NCT number: NCT02357550
• Study type: Interventional
• Source: University of Aarhus
• Status: Completed
• Phase: N/A
• Start date: March 2015
• Completion date: January 2016