Platelet Bioenergetics in TBI

Status Terminated

Clinical Trial Summary

This is a prospective study enrolling 5 patients with a diagnosis of traumatic brain injury (TBI) without polytrauma and 5 patients with TBI with polytrauma admitted to the University of Kentucky (UK) Chandler Medical Center to evaluate differences in platelet bioenergetics in the populations. Additionally, five healthy subjects will be recruited to the control group.

Clinical Trial Description

Traumatic brain injury (TBI) is used to describe a myriad of primary and secondary brain-related injuries related to trauma. Clinically, moderate-to-severe brain injury results in early coagulopathy, with a tendency toward unanticipated bleeding, followed by delayed hypercoagulation, with a tendency toward unanticipated clot formation. Optimal platelet count, activation and function are necessary for normal coagulation. Investigators have recently developed a novel approach to measure platelet activity. This approach specifically measures platelet energy output or bioenergetics from blood samples. Preclinical (animal) studies show that platelet bioenergetic profiles are different after TBI and that they change over time. This temporal profile may be used as a biomarker that can inform diagnosis and prognosis of TBI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04271059
Study type	Observational
Source	University of Kentucky
Contact
Status	Terminated
Phase
Start date	February 13, 2020
Completion date	February 13, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04111549` - GOALS Cognitive Training Delivered to Aging Veterans in Person or Via Telehealth	N/A
Recruiting	`NCT05097261` - Ketamine in Acute Brain Injury Patients.	Phase 4
Completed	`NCT03504709` - REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness
Recruiting	`NCT03899532` - Remote Ischemic Conditioning in Traumatic Brain Injury	N/A
Completed	`NCT05057377` - Estimating Highest Capacity Performance During Evaluation of Walking for Individuals With Traumatic Brain Injury
Withdrawn	`NCT02776488` - Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)	Phase 2
Completed	`NCT02426749` - Treatment and Recovery Monitoring of Post TBI Symptoms	N/A
Completed	`NCT01339702` - The EPIC Project: Impact of Implementing the EMS Traumatic Brain Injury Treatment Guidelines
Recruiting	`NCT05977270` - The Effects of Lifebloom One on Physical Activity After Acquired Brain Injury	N/A
Recruiting	`NCT04666766` - Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers	N/A
Active, not recruiting	`NCT04559724` - Gait Training Through a Novel Over-ground Wearable Robotic System in People With Pyramidal Hemisyndromes	N/A
Not yet recruiting	`NCT04515420` - The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury
Not yet recruiting	`NCT05569993` - Glutamine and Traumatic Brain Injury	Early Phase 1
Recruiting	`NCT04331392` - Online Memory Intervention for Individuals With Traumatic Brain Injury	N/A
Completed	`NCT03727737` - Efficacy of Repetitive Transcranial Magnetic Stimulation for Improvement of Memory in Older Adults With TBI	N/A
Completed	`NCT03153397` - Effect of Prebiotic Fiber- Enriched (scFOS) Enteral Feeding on the Microbiome in Neurological Injury Trauma Patients (PreFEED Microbiome Trial)	N/A
Completed	`NCT01336413` - Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans	Phase 2
Completed	`NCT02004080` - CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe
Completed	`NCT04957563` - Clinical Utility of Olfactory Rehabilitation: Treatment for Pacients With Neurosensorial Anosmia	N/A
Completed	`NCT05179330` - Visual Feedback in Lower Limb Rehabilitation	N/A