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Brain Injuries, Traumatic clinical trials

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NCT ID: NCT04914650 Completed - Clinical trials for Spinal Cord Injuries; Traumatic Brain Injury; Acquired Brain Injury, Stroke

TEleRehabilitation Nepal (TERN) to Improve Quality of Life of People With Spinal Cord Injury and Acquired Brain Injury

TERN
Start date: December 1, 2019
Phase: N/A
Study type: Interventional

Nepal is a low-income country with over 3 million individuals with physical disabilities and currently no government-run specialist rehabilitation services. The aim of this research proposal is to work in partnership with a Nepal Non-Governmental Organisation (NGO), the Spinal Injury Rehabilitation Centre (SIRC, Nepal) to achieve the following: 1. estimate the rehabilitation needs in individuals after stroke, brain injury and spinal cord injury in rural communities after discharge from SIRC 2. hold user and stakeholder workshops to explore the role of multidisciplinary teleconferencing methods for remote assessment and management and agree systems for piloting 3. deploy and pilot a novel telerehabilitation system to improve the lives of these individuals, and evaluate it in terms of feasibility and acceptability

NCT ID: NCT04901286 Completed - Clinical trials for Traumatic Brain Injury

The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL

VITAL
Start date: August 19, 2021
Phase: N/A
Study type: Interventional

Aerobic exercise is a promising treatment modality for cognition in persons with TBI, but effects are consistently small. This study aims to investigate the effect of difference environments during moderate intensity cycling sessions on cognition.

NCT ID: NCT04861688 Completed - Clinical trials for Traumatic Brain Injury

NeuroAiD II™ (MLC901) in Mild Traumatic Brain Injury

SAMURAI
Start date: August 23, 2021
Phase: Phase 3
Study type: Interventional

A Randomized Double-blind, Placebo-controlled, Multi-center Trial to determine the efficacy of NeuroAiD II™ (MLC901) in improvement of cognitive functioning of adult patients with long-term cognitive impairment following mild traumatic brain injury (mTBI) and to assess safety of NeuroAiD™ (MLC901) in these patients.

NCT ID: NCT04854954 Completed - Clinical trials for Traumatic Brain Injury

Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury

PREDICT-TCM
Start date: February 3, 2021
Phase:
Study type: Observational

Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days. However, identifying at risk patients of SND is still challenging. This study aimed to determine risk factors associated with SND after mTBI.

NCT ID: NCT04849221 Completed - Clinical trials for Intracranial Pressure

Wideband Tympanometry for Monitoring Intracranial Pressure in Adult Patients in Intensive Care, Operated on for an Intracranial Lesion After Traumatic Brain Injury, or With Intracranial Hemorrhage

TYMPIC
Start date: March 4, 2021
Phase:
Study type: Observational

Intracranial pressure is usually measured by invasive methods requiring an intracranial sensor. There is no non-invasive monitoring method recognized as a gold standard. Tympanometry would make it feasible to evaluate intracranial pressure through sensitive and specific changes in the energy absorbance of the middle ear. It could represent a non-invasive method of monitoring intracranial pressure. This is a prospective monocentric longitudinal study. All adult patients in intensive care for head trauma, intracranial hypertension, or after cranial surgery and requiring invasive monitoring of ICP will be included after their non-opposition has been collected. In a group of 10 controls, multifrequency tympanometry will be performed in the standing position, in the 0° supine position and in the Tredelenburg position at -17°.

NCT ID: NCT04836481 Completed - Clinical trials for Traumatic Brain Injury

A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury

Start date: January 1, 2021
Phase:
Study type: Observational

This study aims is to describe the pharmacokinetic properties of levetiracetam through measurement of serum concentrations in critically ill, severe traumatic brain injury patients.

NCT ID: NCT04826068 Completed - Clinical trials for Traumatic Brain Injury

Emotional Processing Intervention for Children With TBI

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

Investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (TBI).

NCT ID: NCT04823507 Completed - Clinical trials for Mild Traumatic Brain Injury

Photobiomodulation for Concussions: the Use of the ImPACT® Test as an Assessment Tool

Start date: March 26, 2021
Phase:
Study type: Observational

Brain photobiomodulation (PBM) therapy is an innovative modality for the stimulation of neural activity in order to improve brain function and is currently under investigation as a treatment for several diverse neurological disorders. Our emphasis on this study is to review the use of PBM as a treatment modality for concussions and the use of ImPACT® (Immediate Post-Concussion Assessment and Cognitive Testing) test to assess improvement in cognition and symptomatology in patients with post-concussion syndrome (PCS) treated with PBM.

NCT ID: NCT04810039 Completed - Clinical trials for Prognosis of Neurological Outcome at 6 Months in Patients Undergoing Traumatic Brain Injury

Comparison of the Accuracy of the Neurological Prognosis at 6 Months of Traumatic Brain Injury Between Junior and Senior Doctors

PREDICT II
Start date: March 1, 2021
Phase:
Study type: Observational

PREDICT II is an observational, prospective design, single-center study aiming to determine whether the prognosis of neurological outcome at 6 months in patients undergoing traumatic brain injury established by a doctor at his initial management is more accurate in experienced doctors versus junior doctors.

NCT ID: NCT04796207 Completed - Clinical trials for Traumatic Brain Injury (TBI)

The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes

Start date: May 28, 2019
Phase: N/A
Study type: Interventional

Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football athletes.