Brain Death Clinical Trial
— INSPECTOfficial title:
Investigative Neurological Study With Pupillometric Evaluation os a Clinical Tool in Patients Declared Brain Dead (INSPECT) - a Prospective Quality Control Study
The aim of the study is to verify the reliability of the current purely clinical examination of the pupils (without the support of a pupillometer) in the context of clinically suspected brain death, compared to the results of a non-invasive, automated, and highly precise monocular pupillometric examination.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | December 2030 |
Est. primary completion date | December 2029 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Suspected diagnosis of brain death - Brain death diagnostic procedures planned - Treated at the intensive care unit at the University Hospital Basel (USB) |
Country | Name | City | State |
---|---|---|---|
Switzerland | Intensive care unit at the University Hospital Basel | Basel | Basel-Stadt |
Switzerland | University Hospital Basel | Basel |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Basel, Switzerland |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Reliability of clinical examination of pupils in patients with suspected brain death | Determination of the reliability of the current purely clinical examination of the pupils (without the support of a pupillometer) in the context of clinically suspected brain death compared to the results of a noninvasive, automated, and highly precise pupillometric examination (measurement of the discordance between automated analyses of pupillary light reflex by a hand-held pupillometer and visual examination without pupillometer support in percentage) | baseline (2 hours before start of brain death evaluation) and 5 hours (2 hours after end of brain death evaluation) |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03765814 -
The Anticipated Organ Donation Approach
|
||
Completed |
NCT02581111 -
Naloxone for Optimizing Hypoxemia Of Lung Donors
|
Phase 2/Phase 3 | |
Completed |
NCT00808691 -
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
|
N/A | |
Completed |
NCT00998972 -
N-acetyl-cysteine (NAC) and Kidney Graft Function
|
Phase 3 | |
Completed |
NCT04528797 -
Thyroid and Adrenocortical Hormone Replacement in Organ Donors
|
N/A | |
Completed |
NCT03672812 -
The Use of Liraglutide in Brain Death
|
Phase 3 | |
Completed |
NCT04303624 -
Understanding Family Refusal
|
||
Completed |
NCT03098706 -
Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function
|
N/A | |
Not yet recruiting |
NCT04623294 -
Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
|
||
Recruiting |
NCT02102945 -
Special Imaging Technique to Aid in the Diagnosis of Patients in Coma After Cardiac Arrest
|
N/A | |
Completed |
NCT02483273 -
Alterations of Conjunctival Microcirculation in Brain Dead Patients
|
N/A | |
Terminated |
NCT00675272 -
Organ Donation and Hydrocortisone Treatment
|
N/A | |
Completed |
NCT03262896 -
Neurophysiological Examination in Patients With Brain Death
|
||
Not yet recruiting |
NCT06359119 -
Implementation of Apnoea Test for Patients With Suspected Brain Death
|
||
Recruiting |
NCT05202886 -
"LiverColor": Machine Learning in Liver Photographs
|
N/A | |
Completed |
NCT03281993 -
Apnea Tests as the Methods of Brain Death Diagnosis.
|
N/A | |
Completed |
NCT03179020 -
Donation Network to Optimize Organ Recovery Study
|
N/A | |
Completed |
NCT05070182 -
Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
|
||
Terminated |
NCT03439995 -
Goal of Open Lung Ventilation in Donors
|
N/A | |
Completed |
NCT02525510 -
Deceased Organ Donor Interventions to Protect Kidney Graft Function
|
N/A |