Brain Death Clinical Trial
Official title:
Alterations of Conjunctival Microcirculation in Brain Dead Patients
Study hypothesize that ocular microcirculation is reflecting cerebral perfusion. The purpose of this study is to evaluate ocular microcirculation in brain dead patients using side dark field (SDF) videomicroscope and compare it with microcirculatory parameters of healthy volunteers.
Microcirculation videomicroscopy techniques are used to evaluate a global organ perfusion in
various critical conditions using limited suitable sites available for visualisation.
However, ocular microcirculation may become a window to specifically cerebral perfusion due
to related blood supply, close anatomical proximity and easy accessibility for
videomicroscopy. Cerebral perfusion mainly depends on cerebral flow and intracranial
pressure and therefore we aim, for the first time, to demonstrate microcirculatory status of
ocular conjunctiva in clinical conditions when cerebral flow is completely absent.
In a single center open label observational study investigators analyzed conjunctival and
sublingual microcirculation using SDF videomicroscopy in brain dead patients after reaching
systemic hemodynamic targets to optimise perfusion of donor organs. All brain death
diagnoses were confirmed by cerebral angiography. Microcirculatory images obtained and
analyzed using standardized published recommendations by experts in this field.
Microcirculation of sublingual and conjunctival areas were recorded in matching number of
healthy volunteers using same techniques.
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Observational Model: Case Control, Time Perspective: Prospective
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