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Organ Donation and Hydrocortisone Treatment — HYDRO  

Brain Death Clinical Trial

Official title:
Organ Donation and Vasopressor Use: Effects of Hydrocortisone Treatment

Clinical Trial Summary

Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure. However,norepinephrine may have negative influence on several organs causing reduced blood flow ischemia. Our hypothesis is that hydrocortisone treatment may reduce the amount of vasoactive drugs needed to keep the blood pressure stable in patients selected for organ donation.

Clinical Trial Description

When patients are treated in the ICU only as possible organ donators they will be assessed for eligibility for the study. Iv hydrocortisone or placebo will be administered every 6 hours. Several hormonal samples will be collected. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00675272
Study type Interventional
Source Kuopio University Hospital
Contact
Status Terminated
Phase N/A
Start date May 2008
Completion date December 2011
View Details
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