Brain and Central Nervous System Tumors Clinical Trial
Official title:
Evaluation of Cerebral Spinal Fluid (CSF) Proteome and Angiogenesis Proteins in Children With Newly Diagnosed Central Nervous System Tumors
RATIONALE: Studying samples of cerebrospinal fluid from patients with cancer in the
laboratory may help doctors identify biomarkers related to cancer.
PURPOSE: This laboratory study is studying cerebrospinal fluid proteins and angiogenesis
proteins in young patients with newly diagnosed central nervous system tumors.
OBJECTIVES:
Primary
- Investigate the feasibility of centrally collecting and processing high-quality
cerebrospinal fluid (CSF) samples from pediatric patients with newly diagnosed central
nervous system tumors for proteomic studies.
- Identify protein markers that might indicate the presence of a brain tumor using CSF
samples collected from these patients.
OUTLINE: This is a multicenter study.
Patients undergo cerebrospinal fluid (CSF) collection from any or all of the following 5
sites: lumbar, cervical, ommaya, intra-operative (ventricular, cisternal), and/or external
ventricular drain. CSF is obtained within 8 weeks of diagnosis but prior to (or concurrent
with) the initiation of any post-operative therapy (excluding corticosteroids).
CSF samples are examined for proteomic biomarkers by 2D gel electrophoresis, low-mass
fingerprinting, and stable isotope labeling.
PROJECTED ACCRUAL: A total of 99 patients will be accrued for this study.
;
Observational Model: Cohort, Time Perspective: Prospective
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