Brain and Central Nervous System Tumors Clinical Trial
Official title:
A Pharmacokinetic Study of Methotrexate Using an Intratumoral Microdialysis Catheter
RATIONALE: Collecting fluid from a brain tumor using a small catheter may help doctors learn
how much methotrexate gets into the tumor to kill the tumor cells. It may also help doctors
learn how methotrexate works in the brain and in the rest of the body.
PURPOSE: This clinical trial is studying how much methotrexate gets into the brain tumor by
collecting fluid directly from the tumor through a small catheter in patients undergoing
stereotactic biopsy for recurrent high-grade glioma.
OBJECTIVES:
- Determine the feasibility of using microdialysis to study distribution of systemically
administered methotrexate in the interstitial fluid within a tumor in patients
undergoing stereotactic biopsy for recurrent high-grade gliomas.
- Determine the systemic and intratumoral pharmacokinetics of this drug in these
patients.
OUTLINE: This is a multicenter study.
Patients have an intratumoral microdialysis catheter placed while undergoing stereotactic
biopsy. Between 18-32 hours after placement of catheter, patients receive methotrexate IV
over 4 hours. Microdialysis perfusate and blood specimens are collected before, during, and
for 24 hours after methotrexate administration.
Patients are followed at 2 weeks.
PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study within 6 months.
;
Allocation: Non-Randomized, Primary Purpose: Treatment
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