Brain and Central Nervous System Tumors Clinical Trial
Official title:
Improved Characterization of Brain Tumors By MRI and MRS
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging (MRI) and magnetic
resonance spectroscopic imaging (MRSI), (done before, during, and after treatment) may help
doctors predict a patient's response to treatment and help plan the best treatment.
PURPOSE: This phase II trial is studying how well MRI and MRSI evaluate patients who are
undergoing treatment for gliomas.
OBJECTIVES:
- Determine the magnetic resonance spectroscopic imaging (MRSI) characteristics of
patients who are undergoing treatment for supratentorial glioma.
- Determine the survival of patients who undergo magnetic resonance imaging and MRSI.
- Determine the clinical outcome of patients who undergo these imaging procedures.
- Correlate measures of metabolic tumor burden (i.e., CNI, CCCrI, CrNI, and LLI) with
survival and clinical outcome in patients who undergo these imaging procedures.
- Determine the time to clinical progression in patients who undergo these imaging
procedures.
OUTLINE: Patients are assigned to 1 of 2 treatment groups based on grade of disease.
- Group 1 (patients with grade II glioma): Patients undergo magnetic resonance imaging
(MRI) and magnetic resonance spectroscopic imaging (MRSI). Patients then receive
chemotherapy. Patients undergo repeat MRI/MRSI after courses 2 and 4 of chemotherapy.
- Group 2 (patients with grade III-IV glioma): Patients undergo MRI/MRSI and then undergo
surgical resection of the tumor. Patients then receive chemoradiotherapy. Patients
undergo repeat MRI/MRSI within 2 weeks and at 2 months after completion of
radiotherapy.
Patients are followed for recurrence, disease progression, and survival.
PROJECTED ACCRUAL: A total of 250 patients will be accrued for this study.
;
Masking: Open Label, Primary Purpose: Diagnostic
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