Brain and Central Nervous System Tumors Clinical Trial
Official title:
Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis
RATIONALE: Perfusion magnetic resonance imaging may be an effective method of measuring the
growth of blood vessels in brain tumors. These measurements may help doctors better diagnose
and treat brain tumors.
PURPOSE: Pilot study to determine the effectiveness of perfusion magnetic resonance imaging
in measuring the growth of blood vessels in newly diagnosed brain tumors.
OBJECTIVES: I. Correlate the findings of perfusion magnetic resonance imaging with known
tissue and serum markers of angiogenesis in patients with newly diagnosed surgically
resectable brain tumors.
OUTLINE: Patients undergo perfusion magnetic resonance imaging (MRI) scanning with contrast
in conjunction with preoperative conventional MRI scanning with contrast. Patients receive
gadopentetate dimeglumine IV over 5 seconds prior to perfusion MRI. Gadopentetate
dimeglumine is administered at a slower rate prior to conventional MRI. Patients undergo
blood draw to determine urokinase type plasminogen activator levels. After completion of
perfusion and conventional MRI scanning, brain tumor tissue samples are obtained during
surgical resection to determine tumor grade and type and urokinase type plasminogen
activator and basic fibroblast growth factor levels. If CSF removal is required during
surgery, then CSF samples are collected to determine urokinase type plasminogen activator
and basic fibroblast growth factor levels.
PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
;
Primary Purpose: Diagnostic
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