Brain and Central Nervous System Tumors Clinical Trial
Official title:
Phase II Trial of BCNU Plus O6-Benzylguanine in the Treatment of Patients With Recurrent or Progressive Cerebral Anaplastic Gliomas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining carmustine and
O6-benzylguanine in treating patients who have recurrent or progressive glioma.
OBJECTIVES: I. Determine the activity of carmustine and O6-benzylguanine in patients with
recurrent or progressive glioblastoma multiforme, anaplastic astrocytoma, or gliosarcoma
resistant to nitrosourea. II. Determine the toxic effects of this regimen in these patients.
OUTLINE: Patients receive O6-benzylguanine IV over 1 hour, followed 1 hour later by
carmustine IV over 1 hour on day 1. Treatment repeats every 6 weeks in the absence of
disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 18-32 patients will be accrued for this study within 12-18
months.
;
Primary Purpose: Treatment
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