Brain and Central Nervous System Tumors Clinical Trial
Official title:
Phase II Treatment of Adults With Recurrent Supratentorial Low Grade Glioma With Gliadel Wafers
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of carmustine in treating adults with
recurrent supratentorial low-grade glioma.
OBJECTIVES:
- Determine the antitumor activity of Gliadel wafers (carmustine) in the treatment of
recurrent supratentorial low grade glioma.
- Assess the toxicity of this therapy in these patients.
OUTLINE: Patients are stratified by disease (fibrillary astrocytoma vs oligodendroglioma or
mixed glioma).
Patients receive up to 8 Gliadel wafers (containing carmustine) implanted in the resected
tumor cavity.
Patients are followed every 2 months.
PROJECTED ACCRUAL: This study will accrue a maximum of 68 patients within 18-24 months.
;
Primary Purpose: Treatment
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