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Botulinum Toxin A for Emotional Stabilization in Borderline Personality Disorder (BPD) — BTX-BPD  

Borderline Personality Disorder Clinical Trial

Official title:
Botulinum Toxin A for Emotional Stabilization in Borderline Personality Disorder (BPD)

Clinical Trial Summary

The main objective of the trial is to test whether a single application of botulinum toxin A into the glabellar region will lead to emotional stabilization in borderline personality disorder through paralysis of facial muscles/attenuation of negative emotions.

Clinical Trial Description

Afferent feedback from facial muscles is believed to enhance emotional states (facial feedback theory). The facial expression of negative emotions involves facial muscles of the glabellar region. It has been shown that paralysis of facial muscles in the forehead using botulinum toxin A leads to the improvement of depressive symptoms. It is believed that the limited ability to express these emotions alleviates depressive symptoms. As Borderline personality disorder is characterized by negative emotions expressed via facial muscles in the forehead, it is hypothesized that BPD patients could profit from botulinum toxin treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02728778
Study type Interventional
Source Hannover Medical School
Contact
Status Completed
Phase Phase 2
Start date September 1, 2016
Completion date October 31, 2019
View Details
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