Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder

Borderline Personality Disorder Clinical Trial

— MOTR  

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01896024
• Other study ID #: SNSF 100014-134562
• Status: Completed
• Phase: N/A
• First received: July 5, 2013
• Last updated: December 1, 2014
• Start date: June 2010
• Est. completion date: April 2014

Study information

• Verified date: December 2014
• Source: University of Lausanne Hospitals
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Swiss National Science Foundation
• Study type: Interventional

Clinical Trial Summary

The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder.

The investigators intend to include N = 80 outpatients diagnosed with Borderline Personality Disorder, consulting at the Outpatient Personality Disorder Program of the Karl Jaspers Clinical Unit, in collaboration with the Institute of Psychotherapy, at the Department of Psychiatry-CHUV, University of Lausanne and in collaboration with the University of Berne, Switzerland. Patients are assigned by chance to two treatment conditions 1) Control condition (General Psychiatric Management; Gunderson & Links, 2008) and 2) MOTR-condition. The investigators hypothesize better results in the MOTR-condition, as compared to the control condition in terms of symptom reduction pre-post.

The conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with Borderline Personality Disorder which may be of potential benefit for these patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 85
• Est. completion date: April 2014
• Est. primary completion date: May 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• DSM-IV Borderline Personality Disorder;

• between 18 and 65 yrs of age

Exclusion Criteria:

• DSM-IV psychotic disorders,

• mental retardation,

• substance abuse in the forefront

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Borderline Personality Disorder
• Personality Disorders

Intervention

Behavioral:
• Psychiatric Management

• Motive-oriented therapeutic relationship/Plan Analysis

Locations

Country	Name	City	State
Switzerland	Department of Psychiatry-CHUV, University of Lausanne	Lausanne	VD

Sponsors (1)

Lead Sponsor	Collaborator
University of Lausanne Hospitals

Country where clinical trial is conducted

Switzerland, 

References & Publications (3)

Kramer U, Berger T, Kolly S, Marquet P, Preisig M, de Roten Y, Despland JN, Caspar F. Effects of motive-oriented therapeutic relationship in early-phase treatment of borderline personality disorder: a pilot study of a randomized trial. J Nerv Ment Dis. 20 — View Citation

Kramer U, Flückiger C, Kolly S, Caspar F, Marquet P, Despland JN, de Roten Y. Unpacking the effects of therapist responsiveness in borderline personality disorder: motive-oriented therapeutic relationship, patient in-session experience, and the therapeuti — View Citation

Kramer U, Kolly S, Berthoud L, Keller S, Preisig M, Caspar F, Berger T, de Roten Y, Marquet P, Despland JN. Effects of motive-oriented therapeutic relationship in a ten-session general psychiatric treatment of borderline personality disorder: a randomized — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Borderline Symptom List (Bohus, 2009)	Symptom reduction of borderline symptoms over 3 months of treatment	3 months	No
Primary	Outcome Questionnaire -45.2 (Lambert et al., 2004)	pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months	3 months	No
Secondary	Inventory of Interpersonal Problems (Horowitz et al., 1988)	Measure of interpersonal problems after 3 months of therapy	3 months	No