Transcranial Magnetic Stimulation for Borderline Personality Disorder

Borderline Personality Disorder Clinical Trial

— SiMaT-B  

Official title:

Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Borderline Personality Disorder (BPD)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01076933
• Other study ID #: 08 153 02
• Secondary ID: AOL 2008
• Status: Completed
• Phase: N/A
• First received: January 6, 2010
• Last updated: May 10, 2017
• Start date: January 2010
• Est. completion date: April 2012

Study information

• Verified date: May 2017
• Source: University Hospital, Toulouse
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Primary purpose : to assess the effect on neuropsychological tasks related to planning of 10 daily sessions of right dorsolateral prefrontal cortex with High-frequency repetitive transcranial magnetic stimulation (rTMS) on borderline personality disorder (BPD) patients.

Hypothesis : BPD patients receiving 10 sessions of rTMS will have greater improvement in the average number of move to achieve tasks of the Tower of London, than those receiving sham rTMS.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: April 2012
• Est. primary completion date: March 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• 20 to 45 years old

• Borderline Personality Disorder (Diagnostic Interview for Borderline Personality Disorder > 8)

• psychiatric follow-up

• righthander

• informed consent

• affiliated to medical insurance

Exclusion Criteria:

• bipolar disorder

• substance use disorder

• Major Depressive Disorder or Stress Post Traumatic Disorder

• history of epilepsy

• neurosurgery

• cardiac pacemaker

• lefthander

• involuntary admission

• participation in an other research

• legal guardianship

• poor mastery of french.

Related Conditions & MeSH terms

• Borderline Personality Disorder
• Disease
• Personality Disorders

Intervention

Procedure:
• repetitive Transcranial Stimulation Magnetic (rTMS)
The motor threshold was determined in each subject once, before treatment. This was defined as the lowest stimulation intensity capable of inducing a visible movement at least five times out of 10 stimulations. The position of the right dorsolateral prefrontal cortex was defined as 5 cm anterior (in a parasagittal line) to the motor cortex. The stimulus intensity was 80% of the patient's motor threshold intensity. Treatments were given for 20 minutes per day over 10 working days.
• sham rTMS
sham rTMS

Locations

Country	Name	City	State
France	Lionel Cailhol	Toulouse	University Hospital Toulouse

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Toulouse

Country where clinical trial is conducted

France, 

References & Publications (1)

Cailhol L, Roussignol B, Klein R, Bousquet B, Simonetta-Moreau M, Schmitt L, Thalamas C, Tap G, Birmes P. Borderline personality disorder and rTMS: a pilot trial. Psychiatry Res. 2014 Apr 30;216(1):155-7. doi: 10.1016/j.psychres.2014.01.030. Epub 2014 Jan — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Tower of London		Inclusion, 15th day, 30th day and 3rd month
Secondary	Balloon Analog Risk Task		Inclusion, 15th day, 30th day and 3rd month
Secondary	Micro-World Test		Inclusion, 15th day and 3rd month
Secondary	Borderline Personality Disorder Severity Index		Pre-inclusion, 30th day and 3rd month
Secondary	Symptom Check List - 90		Inclusion, 15th day, 30th day and 3rd month
Secondary	Barratt Impulsivity Scale		Inclusion and 3rd month
Secondary	Global Assessment Scale		Inclusion and 3rd month