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NCT00255554 Clinical Trial

DBT and Escitalopram in Borderline Personality Disorder

Borderline Personality Disorder Clinical Trial

Official title:
Effects of Dialectical Behavioral Therapy and Escitalopram on Impulsive Aggression, Affective Instability and Cognitive Processing in Borderline Personality Disorder

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00255554
Other study ID # 3277-03-0027
Secondary ID
Status Recruiting
Phase N/A
First received November 17, 2005
Last updated November 17, 2005

Study information
Verified date November 2005
Source Bronx VA Medical Center
Contact Emily Hart
Phone 212-241-0441
Email mpgroup@mssm.edu
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

Subjects will receive six months of DBT, consisting of one 90-minute group and one 60-minute individual session per week as well as telephone availability of the individual therapist. Half the subjects will concurrently receive escitalopram while half will receive placebo, in a randomized double-blind design.

Recruitment information / eligibility
Status Recruiting
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: Is a male or female between 18 and 60 who meets criteria for Borderline Personality Disorder and has been off psychotropic medications for at least 2 weeks (6 weeks for fluoxetine).

Exclusion Criteria: Meets criteria for Schizophrenia, Bipolar Disorder, Mental Retardation, current or recent Substance Dependence or a current Major Depressive Episode. Subjects also should not currently be in individual psychotherapy. (Case management and work therapy programs are allowed.)

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Behavioral:
• Dialectical Behavioral Therapy

Drug:
• Escitalopram

Locations
Country Name City State
United States Bronx VA Medical Center Bronx New York

Sponsors (1)
Lead Sponsor Collaborator
Bronx VA Medical Center

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measures of impulsivity, aggression, affective impulsivity, immediate and delayed memory, and cognitive processing at baseline, 6 months and 9 months
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