Adherence, Medication Clinical Trial
Official title:
Pilot Study on the ADherence to Oral Antibiotics in Patients With BONE and Joint Infections (ADABONE)
Bone and joint infection (BJI) are bacterial infections that can occur after surgery
(nosocomial infections) or de novo. They constitute a public health problem in Western
Countries . These infections are often difficult to treat, with a high rate of
re-hospitalizations (19.5%) caused by relapses or recurrences. The treatment of Bone and
joint infection can be surgical and / or pharmacological . Drug treatment is based on the use
of parenteral and / or oral antibiotics. It is a curative therapy in most cases, with a
prolonged duration ranging from 6 weeks to several months depending on the lesions .
Medication adherence, is a patients' behavior defined as drug intake with optimal attendance
and regularity, as prescribed and explained by the physician. It is a key factor in the
success of any drug therapy, as drugs don't work in patients who don't take them..
To the knowledge of investigators, there are no published data on the adherence to antibiotic
therapy in patients treated for Bone and joint infection. In addition to its prolonged
duration, the antibiotic treatment of the Osteoarticular Infections may require several daily
drug intakes and may be responsible for severe adverse effects, these three factors being
known to adversely affect adherence.
Prevalence, adherence patterns over time and determinants of adherence in this patient
population are not known. Currently, drug adherence is not routinely evaluated and is not
considered in the treatment of Bone and joint infection in the Regional Center for Complex
Bone and joint infection of the investigators.
A specific study evaluating adherence to antibiotic therapy in patients treated for Bone and
joint infection appears to be justified.
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