Staphylococcus Aureus Clinical Trial
Official title:
Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration
Staphylococci represent the first etiologic agents of bone and joint infection (BJI),
leading glycopeptides use, especially in case of methicillin-resistance or betalactam
intolerance. Teicoplanin may represent an alternative to vancomycin because of its
acceptable bone penetration and possible subcutaneous administration. Various studies have
shown that teicoplanin pharmacodynamic profile was superior compared to vancomycin regarding
bone diffusion. Few studies have investigated the use of teicoplanin in BJI, particularly
through subcutaneous administration.
The aim of this study assesses the efficacy and tolerance of teicoplanin in S. aureus BJI,
especially focusing on subcutaneous use. This study is a retrospective single-center
observational cohort study (2001 to 2011) including all consecutive patients managed at our
institution receiving teicoplanin as part of S. aureus BJI treatment.
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