Clinical Trials Logo
  1. Home
  2. Bloodstream Infection
  3. NCT02400268

Antibiotic Treatment Duration (7 vs 14 Days) Comparison in Blood Stream Infection Causes by Enterobacteriaceae — SHORTEN  

Bloodstream Infection Clinical Trial

Official title:
Phase 4, Randomized, Controlled Multicentric, Open-label Clinical Trial to Prove That the 7 Day Course of Treatment for Enterobacteriaceae Bacteremia is More Efficient and Equally Safe Than 14 Day Scheme

Clinical Trial Summary

The antimicrobial crisis is a real problem. Infections produced by multiresistant bacteria are becoming more and more frequent, and available antimicrobial agents are usually scarce. Reducing the duration of antimicrobial treatments is one of the most efficient measures to control the antibiotic pressure and to optimise the use of these agents.

Bloodstream infections produced by Enterobacteria (EB) are very frequent, but the optimal duration of antibiotics to treat them is unknown, as long as no clinical trials have been specifically developed to answer this question.

Basing on expert opinions, the Infectious Diseases Society pf America (IDSA) recommends the bacteremia by EB secondary to vascular catheter infections to be treated for 7 to 14 days. This represents a variability of up to 100%. No recommendations have been published regarding the duration of treatment of bacteremia from other sources.

The objective of this project is to prove that the 7-day course of treatment for EB bacteremia is more efficient and equally safe than the 14-day scheme.

Clinical Trial Description

To achieve theses objectives, we propose this randomized, multicentric clinical trial with a superiority design on the duration of antimicrobial treatment for EB bacteremia in adult patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02400268
Study type Interventional
Source Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Contact
Status Completed
Phase Phase 3
Start date September 2014
Completion date March 1, 2017
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT05361135 - 18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia N/A
Recruiting NCT04070820 - Combination Treatment for Enterococcus Faecalis Bacteriemia Multicenter, Observational Study"
Completed NCT03147807 - BetaLACTA® Test for Early De-escalation of Empirical Carbapenems in Pulmonary, Urinary and Bloodstream Infections in ICU N/A
Completed NCT05411315 - Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment N/A
Enrolling by invitation NCT05880069 - Clinical Outcomes in Patients With Infection by Resistant Microorganism
Terminated NCT04250168 - Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response
Terminated NCT04876430 - Best Available Therapy With or Without Meropenem for Bloodstream Infections by Enterobacterales With High Level of Resistance to Carbapenems Phase 2/Phase 3
Completed NCT03255759 - Actionable Results: Bloodstream Infection Molecular Assay Evaluation N/A
Active, not recruiting NCT03744728 - Genotypic Versus Phenotypic Susceptibility Testing of Positive Blood Cultures N/A
Terminated NCT00680459 - Ethanol Locks for the Treatment of Central Venous Line Infections Phase 3
Recruiting NCT04839653 - Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria N/A
Recruiting NCT03896893 - Neonatal Bacterial Colonization Study N/A
Completed NCT05277350 - A Study Investigating the Safety, Recovery, and Pharmacodynamics of Multiple Oral Administrations of SNIPR001 in Healthy Subjects Phase 1
Recruiting NCT00843804 - Surveillance for Nosocomial Infections in Pediatric Cancer Patients N/A
Completed NCT00467272 - Catheter Related - Gram Positive Bloodstream Infections Phase 2
Recruiting NCT04658017 - GARNET™ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection N/A
Completed NCT04710212 - Screening for Colonization With Resistant Enterobacterales in Neutropenic Patients With Hematologic Malignancies
Not yet recruiting NCT06271031 - Process Mapping and Data Collection to Inform a Computer Simulation Model of Hospitalised Patients With Bloodstream Infection, Sepsis and Systemic Infection
Not yet recruiting NCT03991793 - Granzyme A in Patients With E. Coli Bacteremic Urinary Tract Infections
Completed NCT00870623 - Procalcitonin and Endotoxin Sequential Levels to Optimize the Treatment of Bloodstream Infections